NCT05177848 is a NA clinical trial of All nicotine/ tobacco products at market price in Cigarette Smoking, sponsored by Virginia Polytechnic Institute and State University.

Who is sponsoring NCT05177848?

NCT05177848 is sponsored by Virginia Polytechnic Institute and State University.

What drugs are being tested in NCT05177848?

Interventions in NCT05177848: All nicotine/ tobacco products at market price, Nicotine vaping products at 1/2 market price, Nicotine vaping products at 2x market price, Heated tobacco products at 1/2 market price., Heated tobacco products at 2x market price., Nicotine pouch products at 1/2 market price., Nicotine pouch products at 2x market price..

What condition does NCT05177848 study?

NCT05177848 studies Cigarette Smoking, Nicotine Vaping.

Is NCT05177848 still recruiting?

NCT05177848 is currently completed. Last updated 30 January 2025.

Are results published for NCT05177848?

Yes — primary outcome results have been posted to ClinicalTrials.gov. See the outcomes section above for details.

Last reviewed 2025-01-30 · How we verify

NCT05177848

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Comparison of the Substitution Between Different Tobacco/Nicotine Products as a Function of Tobacco-user Type

Completed NA Results posted Last updated 30 January 2025

What this trial tests

NA trial testing All nicotine/ tobacco products at market price in Cigarette Smoking in 60 participants. Completed in 7 June 2023.

Timeline

29 June 2022

Primary endpoint
2 June 2023

7 June 2023

Quick facts

Lead sponsor	Virginia Polytechnic Institute and State University
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	crossover
Masking	none
Primary purpose	basic science
Enrollment	60
Start date	29 June 2022
Primary completion	2 June 2023
Estimated completion	7 June 2023
Sites	1 location across United States

Drugs / interventions tested

All nicotine/ tobacco products at market price
Nicotine vaping products at 1/2 market price
Nicotine vaping products at 2x market price
Heated tobacco products at 1/2 market price.
Heated tobacco products at 2x market price.
Nicotine pouch products at 1/2 market price.
Nicotine pouch products at 2x market price.

Conditions studied

Cigarette Smoking — all drugs for Cigarette Smoking →
Nicotine Vaping — all drugs for Nicotine Vaping →

Sponsor

Virginia Polytechnic Institute and State University

Who can join

21 and older, any sex, with Cigarette Smoking or Nicotine Vaping. Patients with the condition only — healthy volunteers not accepted.

Results — posted to ClinicalTrials.gov

Per-arm endpoint measurements with 95% confidence intervals where reported. Source: trial results section.

Nicotine/Tobacco Products Substitution Primary · 1 day

Participants will complete purchasing trials in an Experimental Tobacco Marketplace (ETM) with cigarettes increasing in price. Other product prices in the ETM will depend on the experimental condition. The degree to which other nicotine/tobacco products substitute for conventional cigarettes as a function of novel product (e.g. nicotine vaping products, heated tobacco products, nicotine pouch products) prices will be assessed. To obtain estimates of substitution of price-constant products in the different ETM conditions, the investigators will use ordinary least squares regression to model th

Control

Group	Value	95% CI
Exclusive Cigarette Smokers	12.11	± 51.66
Dual Cigarette/ Nicotine Vaping Product Users	4.82	± 25.93

HTP 1/2

Group	Value	95% CI
Exclusive Cigarette Smokers	25.28	± 45.78
Dual Cigarette/ Nicotine Vaping Product Users	17.08	± 22.07

HTP 2

Group	Value	95% CI
Exclusive Cigarette Smokers	19.70	± 43.92
Dual Cigarette/ Nicotine Vaping Product Users	10.73	± 24.88

NPP 1/2

Group	Value	95% CI
Exclusive Cigarette Smokers	20.77	± 52.88
Dual Cigarette/ Nicotine Vaping Product Users	11.06	± 28.00

NPP 2

Group	Value	95% CI
Exclusive Cigarette Smokers	16.36	± 50.81
Dual Cigarette/ Nicotine Vaping Product Users	-1.09	± 27.51

NVP 1/2

Group	Value	95% CI
Exclusive Cigarette Smokers	11.62	± 118.50
Dual Cigarette/ Nicotine Vaping Product Users	-0.68	± 81.91

NVP 2

Group	Value	95% CI
Exclusive Cigarette Smokers	24.56	± 39.38
Dual Cigarette/ Nicotine Vaping Product Users	11.58	± 26.46

Cigarette Demand Primary · 1 day

Participants will complete purchasing trials in an Experimental Tobacco Marketplace (ETM) with cigarettes increasing in price. Other product prices in the ETM will depend on the experimental condition. The degree to which other nicotine/tobacco products substitute for conventional cigarettes as a function of novel product (e.g. nicotine vaping products, heated tobacco products, nicotine pouch products) prices will be assessed. To obtain dependent measures of demand, participants' purchasing of the price-manipulated commodity in the ETM task will be fit to a modified exponential equation to qu

Control

Group	Value	95% CI
Exclusive Cigarette Smokers	212.39	± 206.92
Dual Cigarette/ Nicotine Vaping Product Users	193.58	± 258.37

HTP 1/2

Group	Value	95% CI
Exclusive Cigarette Smokers	221.66	± 235.08
Dual Cigarette/ Nicotine Vaping Product Users	163.28	± 170.31

HTP 2

Group	Value	95% CI
Exclusive Cigarette Smokers	186.03	± 206.94
Dual Cigarette/ Nicotine Vaping Product Users	231.96	± 391.03

NPP 1/2

Group	Value	95% CI
Exclusive Cigarette Smokers	229.45	± 225.12
Dual Cigarette/ Nicotine Vaping Product Users	186.18	± 200.50

NPP 2

Group	Value	95% CI
Exclusive Cigarette Smokers	225.77	± 217.11
Dual Cigarette/ Nicotine Vaping Product Users	163.71	± 225.14

NVP 1/2

Group	Value	95% CI
Exclusive Cigarette Smokers	187.58	± 205.34
Dual Cigarette/ Nicotine Vaping Product Users	184.45	± 229.39

NVP 2

Group	Value	95% CI
Exclusive Cigarette Smokers	198.93	± 197.99
Dual Cigarette/ Nicotine Vaping Product Users	237.64	± 309.73

Sponsor's own description

This study will investigate the relative appeal (abuse liability) of novel tobacco products, how the appeal is modulated by relative price, user type, and how novel products may substitute for one another.

Publications & conference data

No peer-reviewed publications indexed yet for this trial. Completed trials usually publish results within 12-18 months.

Verify or expand the search:

Other trials of All nicotine/ tobacco products at market price

Trials testing the same drug.

NCT06456671 — Examining the Generality of Laboratory-based Findings and Their Moderators in the ITC Study · NA · completed

Other recruiting trials for Cigarette Smoking

Currently open trials in the same condition.

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NCT07014124 — Smoking Cessation for Fathers of Sick Children · NA · recruiting
NCT06678789 — Evaluation of Low and High Nicotine Tobacco Free Nicotine Pouches · NA · recruiting
NCT06609083 — Effect of Cannabis on Cigarette Use Behavior · Phase 1 · recruiting
NCT05587361 — Beta-Adrenergic Modulation of Drug Cue Reactivity · Phase 4 · recruiting

Other Virginia Polytechnic Institute and State University trials

Trials by the same sponsor.

NCT07521072 — Testing an Intervention for College Students With Food Insecurity and Binge Eating · EARLY_PHASE1 · not yet recruiting
NCT07042373 — Effects of Tobacco Abuse Liability-dependent Taxes in the ETM · NA · not yet recruiting
NCT07158749 — Generalized and Domain-Specific Episodic Thinking for Smoking Cessation · NA · not yet recruiting
NCT07457710 — Remote Haptic Rehabilitation for Parkinson's Disease · NA · not yet recruiting
NCT05103514 — The Longitudinal Impact of SES and the CNDS on Recovery From SUD · withdrawn

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT05177848 (US National Library of Medicine, public domain)
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Virginia Polytechnic Institute and State University
Last refreshed: 30 January 2025

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05177848.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing