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NCT05177419
Effects of LSD on Neuroplasticity in Healthy Subjects
Phase 1 trial testing Lysergic Acid Diethylamide in Healthy in 45 participants. Completed in 12 March 2025.
12 March 2025
Quick facts
| Lead sponsor | University of Fribourg |
|---|---|
| Phase | Phase 1 |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | crossover |
| Masking | quadruple |
| Primary purpose | basic science |
| Enrollment | 45 |
| Start date | 2 May 2022 |
| Primary completion | 12 March 2025 |
| Estimated completion | 12 March 2025 |
| Sites | 1 location across Switzerland |
Drugs / interventions tested
- Lysergic Acid Diethylamide
- Lysergic Acid Diethylamide
Conditions studied
- Healthy — all drugs for Healthy →
Sponsor
University of Fribourg
Who can join
Adults 21 to 55, any sex, with Healthy. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Neuroplasticity is the brain's ability to reorganize itself and adapt in response to changing environmental conditions or pathological stimuli. LSD is a potent psychedelic drug which has been able to rapidly stimulate neuroplasticity in animal studies. Various authors have speculated that changes in neuroplasticity may contribute to LSD's long-term effects, but there is still little direct evidence that LSD or other psychedelics enhance neuroplasticity in humans. The goal of this study is to investigate the effects of LSD on several measures of neuroplasticity in healthy human subjects.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Unraveling the Mysteries of Mental Illness With Psilocybin.
Sotille R, Singh H, Weisman A, Vida T. · · 2022 · cited 2× · PMID 35769681 · DOI 10.7759/cureus.25414
Verify or expand the search:
- PubMed search for NCT05177419
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other trials of Lysergic Acid Diethylamide
Trials testing the same drug.
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- NCT04516902 — Effects of MDMA Co-administration on the Response to LSD in Healthy Subjects · Phase 1 · completed
- NCT04558294 — Effect of Ketanserin After LSD Administration · Phase 1 · completed
- NCT03790358 — Mood Effects of Serotonin Agonists · Phase 1 · completed
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Other University of Fribourg trials
Trials by the same sponsor.
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT05177419 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by University of Fribourg
- Last refreshed: 6 April 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05177419.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing