Adults 18 to 65, any sex, with Overweight and Obesity or Type2 Diabetes. Patients with the condition only — healthy volunteers not accepted.
Results — posted to ClinicalTrials.gov
Per-arm endpoint measurements with 95% confidence intervals where reported. Source: trial results section.
Change in Body WeightPrimary· 12 months
Difference in body weight between follow-up and baseline (follow-up - baseline); positive values indicate weight gain.
Group
Value
95% CI
Gamified mLIFE App Group
-5.3
± 0.64
Standard mLIFE App
-3.49
± 0.72
Change in Energy IntakeSecondary· 12 months
Difference in total energy intake between follow-up and baseline (follow-up - baseline); positive values indicate increased intake.
Group
Value
95% CI
Gamified mLIFE App Group
-347.73
± 91.15
Standard mLIFE App
-257.42
± 92.93
Change in Weekly Moderate to Vigorous Physical Activity (MVPA)Secondary· 12 months
Difference in average weekly minutes of moderate-to-vigorous physical activity (MVPA) between follow-up and baseline (follow-up - baseline), derived from Fitbit physical activity data; positive values indicate increased MVPA.
Group
Value
95% CI
Gamified mLIFE App Group
-4.66
± 23.45
Standard mLIFE App
-3.5
± 24.91
Adverse events — posted to ClinicalTrials.gov
Time frame: From enrollment until end of study, up to 52 weeks..
Reporting threshold: 5%.
Adverse-event reports describe events observed during the trial — not all are caused by the drug.
The goal of the study is to examine long term sustained weight loss digital intervention in a diverse cohort of adults with overweight/obesity. The intervention includes social gaming (using game-like elements in nongame contexts to promote supportive social interactions and openness to positive behavioral influences) to reward behaviors, such as self-monitoring and social support.
Investigators will accomplish objectives and test hypotheses by following two specific primary aims:
1. Determine if the intervention plus gaming produces significantly more weight loss at 12 months than the same intervention without gaming among 240 adults with overweight or obesity and ≥3 T2DM risk factors.
2. Examine the differences in social support provision and receipt between groups at 12 months.
Publications & conference data
4 peer-reviewed publications reference this trial (live from Europe PMC):
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Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by University of South Carolina
Last refreshed: 15 January 2026
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05176847.