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Platelet and Immune Response in Covid-19 Vaccine (Vax-SPEED-IT)
COVID-19 mRNA vaccines, administered with a two-dose regimen, have been shown to provide protection against Covid-19. However, the thromboinflammatory response toward these vaccines has never been explored as they exploit a completely new technology. It was reported that mRNA vaccines are highly reactogenic right after vaccine administration in particular in young adults, but we do not know which cells drive the early immune response to LNP-mRNA vaccines in humans and if platelets become activated as well. Moreover, it is not known if female, who have a heightened immune response to other vaccines, are able to mount a faster response to this new type of vaccines. Objectives of the study is to characterize the platelet and immune response and the platelet-immune cross-talk in subjects undergoing SARS-CoV-2 vaccination.
Details
| Lead sponsor | University of Roma La Sapienza |
|---|---|
| Status | UNKNOWN |
| Enrolment | 32 |
| Start date | Wed May 05 2021 00:00:00 GMT+0000 (Coordinated Universal Time) |
| Completion | Fri Apr 15 2022 00:00:00 GMT+0000 (Coordinated Universal Time) |
Conditions
- SARS-CoV-2 Vaccination
Countries
Italy