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NCT05170217: eCBD
Reducing the Harmful Effects of Cannabis Use: Finding the Optimal CBD:THC Ratio
NA trial testing THC in Cannabis Use in 46 participants. Completed in 9 June 2019.
9 June 2019
Quick facts
| Lead sponsor | King's College London |
|---|---|
| Phase | NA |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | crossover |
| Masking | double |
| Primary purpose | basic science |
| Enrollment | 46 |
| Start date | 8 November 2017 |
| Primary completion | 9 June 2019 |
| Estimated completion | 9 June 2019 |
| Sites | 1 location across United Kingdom |
Drugs / interventions tested
- THC — full drug profile →
- Cannabidiol (CANNABIDIOL) — full drug profile →
- Cannabidiol (CANNABIDIOL) — full drug profile →
- Cannabidiol (CANNABIDIOL) — full drug profile →
Conditions studied
- Cannabis Use — all drugs for Cannabis Use →
Sponsor
King's College London
Who can join
Adults 21 to 50, any sex, with Cannabis Use. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
This study will recruit healthy volunteers who use cannabis infrequently. Each participant will attend the laboratory on five occasions: an initial visit to check that they are safe to join the study and four days of testing. Participants will be administered, in a randomized order, vaporized cannabis containing one of four different ratios of CBD:THC (0:1, 1:1, 2:1, 3:1). The cannabis administration will follow a standardised inhalation procedure using a medical-grade vaporizer device. Participants will complete a series of tasks measuring cognition, psychosis, anxiety and other subjective experiences. The study will be carried out at the NIHR-Wellcome Trust Clinical Research Facility at King's College Hospital.
Publications & conference data
3 peer-reviewed publications reference this trial (live from Europe PMC):
-
Does cannabidiol make cannabis safer? A randomised, double-blind, cross-over trial of cannabis with four different CBD:THC ratios.
Englund A, Oliver D, Chesney E, Chester L, et al · · 2023 · cited 64× · PMID 36380220 · DOI 10.1038/s41386-022-01478-z -
Effects of Cannabidiol and Delta-9-Tetrahydrocannabinol on Plasma Endocannabinoid Levels in Healthy Volunteers: A Randomized Double-Blind Four-Arm Crossover Study.
Chester LA, Englund A, Chesney E, Oliver D, et al · · 2024 · cited 14× · PMID 36493386 · DOI 10.1089/can.2022.0174 -
Cannabidiol does not attenuate acute delta-9-tetrahydrocannabinol-induced attentional bias in healthy volunteers: A randomised, double-blind, cross-over study.
Oliver D, Englund A, Chesney E, Chester L, et al · · 2024 · cited 3× · PMID 37821096 · DOI 10.1111/add.16353
Verify or expand the search:
- PubMed search for NCT05170217
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Currently open trials in the same condition.
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Other King's College London trials
Trials by the same sponsor.
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT05170217 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by King's College London
- Last refreshed: 27 December 2021
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05170217.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing