NCT05166343 (PRIME) is a Phase 2/Phase 3 clinical trial of Epinephrine Injection in Pediatric Out-of-Hospital Cardiac Arrest, sponsored by London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's.

What drugs are being tested in NCT05166343?

Interventions in NCT05166343: Epinephrine Injection.

What condition does NCT05166343 study?

NCT05166343 studies Pediatric Out-of-Hospital Cardiac Arrest.

Is NCT05166343 still recruiting?

NCT05166343 is currently recruiting now. Last updated 7 March 2025.

Last reviewed 2025-03-07 · How we verify

NCT05166343: PRIME

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Pediatric Out-of-Hospital Cardiac Arrest Resuscitation: Evaluation of IM Epinephrine (The PRIME Trial)

Recruiting now Phase 2/Phase 3 Last updated 7 March 2025

What this trial tests

Phase 2/Phase 3 trial testing Epinephrine Injection in Pediatric Out-of-Hospital Cardiac Arrest in 284 participants. Currently enrolling.

Timeline

8 January 2024

Primary endpoint
1 January 2028

1 January 2029

Quick facts

Lead sponsor	London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Phase	Phase 2/Phase 3
Status	Recruiting now
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	none
Primary purpose	supportive care
Enrollment	284
Start date	8 January 2024
Primary completion	1 January 2028
Estimated completion	1 January 2029
Sites	1 location across Canada

Drugs / interventions tested

Epinephrine Injection — full drug profile →

Conditions studied

Pediatric Out-of-Hospital Cardiac Arrest — all drugs for Pediatric Out-of-Hospital Cardiac Arrest →

Sponsor

London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's

Who can join

Adults 1 Day to 17, any sex, with Pediatric Out-of-Hospital Cardiac Arrest. Patients with the condition only — healthy volunteers not accepted.

What's being measured

Primary outcomes are the specific endpoints the trial is designed to prove or disprove.

Time to initial return of spontaneous circulation (ROSC)
Time frame: At time of event
The primary outcome will be the time to initial ROSC. The investigator will compare time to initial ROSC between the standard of care and intervention periods.

Sponsor's own description

This is a pragmatic, two-arm, open-label, prospective stepped-wedge cluster quasi randomized control trial (SW-CRCT) looking to evaluate early intramuscular (IM) epinephrine in the management of pediatric out-of-hospital cardiac arrest (POHCA).

Publications & conference data

2 peer-reviewed publications reference this trial (live from Europe PMC):

Evaluating intramuscular epinephrine in pediatric out-of-hospital cardiac arrest (the PRIME trial): study protocol for a multi-centre, stepped-wedge cluster quasi-randomized controlled trial.
Idrees S, Assaf M, Davis M, Garcia-Bournissen F, et al · · 2026 · PMID 42260675 · DOI 10.1186/s13063-026-09776-3
Intramuscular epinephrine in cardiac arrest: A systematic review.
Alshaikh R, Sheikh A, Fleming C, Garcia-Bournissen F, et al · · 2025 · PMID 41245627 · DOI 10.1016/j.resplu.2025.101133

Verify or expand the search:

Other trials of Epinephrine Injection

Trials testing the same drug.

NCT06527937 — Pharmacokinetics Study of DESF in Adults With Oral Allergy Syndrome · Phase 2 · completed

Other London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's trials

Trials by the same sponsor.

NCT07588711 — Transcutaneous Auricular Vagus Nerve Stimulation as a Treatment for Neuropathic Pain Following Spinal Cord Injury · NA · not yet recruiting
NCT07585292 — Transcutaneous Auricular Vagus Nerve Stimulation as a Treatment for Musculoskeletal Pain in Cerebral Palsy · NA · not yet recruiting
NCT07510906 — Evaluation of a Prostate-Targeted PET Imaging System (P-PET) for Detecting Prostate Cancer · NA · not yet recruiting
NCT03166072 — Health Education vs Meditation in Irreversible Age-Related Vision Loss Patients and Their Caregivers · NA · not yet recruiting
NCT06035809 — Sensory Motor Arousal Regulation Treatment (SMART) Study · NA · not yet recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT05166343 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Last refreshed: 7 March 2025

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05166343.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing