Presence of Signs of Central Sensitization in Episodic and Chronic Migraine (CENSENMI)

NCT05162664 NA COMPLETED

Nowadays migraine is conceptualized as a continuum, with at the one hand episodic migraine (EM) and at the other hand chronic migraine (CM) (1). The general aim of the study is to determine where exactly in this continuum central sensitization (CS) appears. Recent studies support the presence of CS in migraine patients (2,3), but controversial evidence exists about where in the continuum exactly CS appears. Some studies determined no differences in sings of CS between EM and CM (4,5), whether other research indicate a clear difference between EM and CM (6-8). However a significant difference in CS parameters could be determined between a patient group (EM or CM) and a healthy control group (3,4,8). In addition, CS appears to be present during the migraine attack (2). In this research, the presence of signs of CS will be determined in between headache phases. The primary outcome measure is identification of CS by PPT, QST, TS, CPM and CSI. Secondary outcome measures are the outcome of the MIDAS, HADS and EUROLIGHT.

Details

Lead sponsor	University Ghent
Phase	NA
Status	COMPLETED
Enrolment	60
Start date	Fri Oct 15 2021 00:00:00 GMT+0000 (Coordinated Universal Time)
Completion	Sat Oct 01 2022 00:00:00 GMT+0000 (Coordinated Universal Time)

Conditions

• Central Sensitisation
• Migraine

Interventions

• Pressure pain thresholds
• Thermal detection and pain thresholds
• Temporal summation
• Conditioned pain modulation

Countries

Belgium