NCT05160155

Comparison of the Analgesic Efficacy of Serratus Anterior Plane Block and Intercostal Block

Completed NA Last updated 10 January 2023

What this trial tests

NA trial testing Serratus Anterior Plane Block in Rib Fractures in 60 participants. Completed in 30 December 2022.

Timeline

3 December 2021

Primary endpoint
20 December 2022

30 December 2022

Quick facts

Lead sponsor	Atatürk Chest Diseases and Chest Surgery Training and Research Hospital
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	double
Primary purpose	treatment
Enrollment	60
Start date	3 December 2021
Primary completion	20 December 2022
Estimated completion	30 December 2022
Sites	1 location across Turkey (Türkiye)

Drugs / interventions tested

• Serratus Anterior Plane Block
• Intercostal Block

Conditions studied

• Rib Fractures — all drugs for Rib Fractures →
• Serratus Anterior Plane Block — all drugs for Serratus Anterior Plane Block →
• Erector Spinae Plane Block — all drugs for Erector Spinae Plane Block →
• Acute Pain — all drugs for Acute Pain →

Sponsor

Atatürk Chest Diseases and Chest Surgery Training and Research Hospital

Who can join

Adults 18 to 65, any sex, with Rib Fractures or Serratus Anterior Plane Block. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

More than 50% of patients presenting with chest trauma experience rib fractures and these rib fractures are associated with significant morbidity, mortality, and long-term disability. Many of these adverse outcomes result from poorly controlled pain that interferes with breathing, leading to atelectasis, pneumonia, and respiratory failure. Therefore, early provision of adequate analgesia is crucial in the management of these patients. The basic stones of analgesic therapy are oral and intravenous drugs such as paracetamol, nonsteroidal anti-inflammatory drugs (NSAIDs), and opioids. However, patients with more significant injuries or comorbidities often require interventional procedures to provide adequate analgesia and avoid opioid-related side effects. Thoracic epidural analgesia and thoracic paravertebral blocks have traditionally been used, but these techniques are associated with side effects and may cause hemodynamic instability. Today, the use of ultrasonography (USG) guided block techniques such as erector spinae plane block (ESPB), serratus anterior plane block (SAPB) and intercostal block (ICB) has increased. These techniques are considered to be simpler and theoretically safer. Although ICB is frequently mentioned in the literature, the publications of new plane blocks such as ESPB and SAPB are new and few in number. In this study, SAPB and ICP to be performed with USG will be evaluated in terms of analgesic effect.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

1. Comparison of the analgesic efficacy of ultrasound-guided superficial serratus anterior plane block and intercostal nerve block for rib fractures: a randomized controlled trial.
   Zengin M, Küçük O, Aslan M, Fındık G, et al · · 2025 · cited 6× · PMID 40082780 · DOI 10.1186/s12871-025-03000-6