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NCT05158647
Adding Magnesium Sulfate to Bupivacaine for Ilioinguinal and Iliohypogastric Nerve Block
Phase 2 trial testing normal saline in Magnesium Sulfate Causing Adverse Effects in Therapeutic Use in 90 participants. Completed in 21 April 2020.
7 February 2020
Quick facts
| Lead sponsor | Abdelrady S Ibrahim, MD |
|---|---|
| Phase | Phase 2 |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | double |
| Primary purpose | prevention |
| Enrollment | 90 |
| Start date | 12 August 2018 |
| Primary completion | 7 February 2020 |
| Estimated completion | 21 April 2020 |
| Sites | 1 location across Egypt |
Drugs / interventions tested
- normal saline
- MgSo4 — full drug profile →
Conditions studied
- Magnesium Sulfate Causing Adverse Effects in Therapeutic Use — all drugs for Magnesium Sulfate Causing Adverse Effects in Therapeutic Use →
Sponsor
Abdelrady S Ibrahim, MD — full company profile →
Who can join
Eligibility, male only, with Magnesium Sulfate Causing Adverse Effects in Therapeutic Use. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Regional block of ilioinguinal and iliohypogastric (IIIH) nerves has been applied to provide postoperative analgesia after inguinal hernia repair. Magnesium sulfate (MgSo4) blocks N-methyl-d-aspartate receptors, and that is why, it was used as an adjuvant to the local anesthetic (LA) in different anesthetic approaches. Although the prolongation in postoperative duration resulting from the addition of MgSO4 to LA was significant in some literature studies, it was insignificant in others. This study was designed to investigate the adjunctive effect of MgSo4 when added to bupivacaine for IIIH blockade on the postoperative analgesic duration as a primary outcome and on the verbal rating scale (VRS) scores, analgesic consumption, and hemodynamics as secondary outcomes.
Publications & conference data
No peer-reviewed publications indexed yet for this trial. Completed trials usually publish results within 12-18 months.
Verify or expand the search:
- PubMed search for NCT05158647
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
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Other Abdelrady S Ibrahim, MD trials
Trials by the same sponsor.
- NCT04608006 — Epidural Analgesia and Delivery of Second Twin · completed
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT05158647 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Abdelrady S Ibrahim, MD
- Last refreshed: 15 December 2021
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05158647.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing