Last reviewed · How we verify
NCT05157594: PROGLIO
hPG80 (Circulating Progastrin) as a Blood Biomarker for High-grade Glial Tumors
trial testing Blood sample in Glial Cell Tumors in 30 participants. Completed in 19 August 2025.
19 August 2025
Quick facts
| Lead sponsor | Centre Jean Perrin |
|---|---|
| Status | Completed |
| Study type | OBSERVATIONAL |
| Enrollment | 30 |
| Start date | 14 February 2022 |
| Primary completion | 19 August 2025 |
| Estimated completion | 19 August 2025 |
| Sites | 1 location across France |
Drugs / interventions tested
- Blood sample — full drug profile →
Conditions studied
- Glial Cell Tumors — all drugs for Glial Cell Tumors →
Sponsor
Centre Jean Perrin — full company profile →
Who can join
18 and older, any sex, with Glial Cell Tumors. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
PROGLIO is a French mono-centric study with longitudinal follow-up, in which patients with high grade brain tumors will be included. Blood samples will be taken during their therapeutic follow-up to evaluate plasma concentrations of hPG80 (circulating progastrin).
Publications & conference data
3 peer-reviewed publications reference this trial (live from Europe PMC):
-
Association between post-operative hPG<sub>80</sub> (circulating progastrin) detectable level and worse prognosis in glioblastoma.
Doucet L, Cailleteau A, Vaugier L, Gourmelon C, et al · · 2023 · cited 4× · PMID 37713930 · DOI 10.1016/j.esmoop.2023.101626 -
hPG<sub>80</sub> (circulating progastrin) as a blood biomarker for high-grade glial tumors: A pilot study.
Casile M, Passildas J, Vire B, Molnar I, et al · · 2022 · cited 2× · PMID 36712425 · DOI 10.3389/fneur.2022.1073476 -
Diagnostic value of the wnt target and cancer-associated blood biomarker hPG80: ONCOPRO case-control prospective study.
You B, Couraud S, Ceruse P, Badet L, et al · · 2025 · cited 1× · PMID 40598473 · DOI 10.1186/s40364-025-00793-z
Verify or expand the search:
- PubMed search for NCT05157594
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other trials of Blood sample
Trials testing the same drug.
- NCT07226466 — Evaluating Biomarkers of Cognitive Dysfunction in Patients With Cancer · not yet recruiting
- NCT07313878 — Evaluation of Acute and Chronic Nephrotoxicity in Acute Lymphatic Leukemia Patients Using Ultrasound Localization Micros · NA · recruiting
- NCT06273800 — Chemosensitivity During Phases of the Menstrual Cycle in Breast Cancer Patients · NA · recruiting
- NCT07030205 — Resting-state Imaging and OSteoporosiS · NA · recruiting
- NCT07295808 — Identification and Characterisation of IgA With Nephritogenic Potential in IgA Deposition Nephropathies (Rep-IgAN) · NA · recruiting
Other Centre Jean Perrin trials
Trials by the same sponsor.
- NCT07361471 — Identification of Genetic, Phenotypic, Clinical, Biological and Histological Factors Differentiating Patients With Ovari · NA · recruiting
- NCT06512558 — Augmented Reality Feasibility for Non-invasive Preoperative Tracking in Breast Cancer Surgery · NA · recruiting
- NCT06600802 — Intrinsic Validity of Molecular Marker(s) Detection on Tissular Tumoral DNA to Predict the Efficacy of 177Lutetium-PSMA- · NA · recruiting
- NCT05433077 — Support and Post-therapeutic Rehabilitation for Women in Complete Remission of Breast Cancer in a Thermal Environment · active not recruiting
- NCT04133077 — Xenografts Development From Surgical Tumor Samples of Patients With Triple Negative or Luminal B Breast Cancer · NA · recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT05157594 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Centre Jean Perrin
- Last refreshed: 22 September 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05157594.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing