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Examining the Effect of Exogenous Ketone Supplementation on Glucose Control in Type 2 Diabetes
Ketone bodies are a fuel source and signaling molecule that are produced by the body during prolonged fasting or if an individuals consistently eats a low-carbohydrate "keto" diet. Blood ketones can be used as a source of energy by the body, but they may also act as signals that impact the functioning of different cells in the body. Recently, the availability of ketone supplements that can be taken orally allows for raising blood ketones without having to fast or eat a "keto" diet. The investigators' studies and those of other researchers have shown that ketone supplementation can lower blood sugar without having to make any other dietary changes. Oral ingestion of ketones may therefore be an effective strategy to improve blood sugar control and influence how cells function. The main objective of this study is to determine if consuming a ketone supplement 3 times per day (before meals) for 14 days lowers blood sugar and impacts how the body's cells function. The results of this study will be used to guide future recommendations on the utility of ketone supplements for improving health in individuals with, or at elevated risk of, type 2 diabetes.
Details
| Lead sponsor | University of British Columbia |
|---|---|
| Phase | NA |
| Status | COMPLETED |
| Enrolment | 15 |
| Start date | Tue Feb 15 2022 00:00:00 GMT+0000 (Coordinated Universal Time) |
| Completion | Fri Feb 03 2023 00:00:00 GMT+0000 (Coordinated Universal Time) |
Conditions
- Diabetes Mellitus, Type 2
Interventions
- Exogenous Ketone Monoester
- Placebo
Countries
Canada