NCT05153837: WATERNAL

Effect of Oral Water in Healthy Volunteers on Cardiac Output, Regional Flow and Microcirculation in Healthy Volunteers

Completed NA Last updated 28 May 2025

What this trial tests

NA trial testing saline intravenous administration in Intravenous Fluids in 59 participants. Completed in 28 August 2023.

Timeline

30 November 2021

Primary endpoint
28 August 2023

28 August 2023

Quick facts

Lead sponsor	Centre Hospitalier Universitaire, Amiens
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	none
Primary purpose	other
Enrollment	59
Start date	30 November 2021
Primary completion	28 August 2023
Estimated completion	28 August 2023
Sites	1 location across France

Drugs / interventions tested

• saline intravenous administration
• oral water

Conditions studied

• Intravenous Fluids — all drugs for Intravenous Fluids →
• Pharmacodynamics — all drugs for Pharmacodynamics →
• Fluid Therapy — all drugs for Fluid Therapy →
• Fluid Responsiveness — all drugs for Fluid Responsiveness →

Sponsor

Centre Hospitalier Universitaire, Amiens

Who can join

Adults 18 to 30, any sex, with Intravenous Fluids or Pharmacodynamics. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Human digestive system physiologically ensures the absorption of oral water and hydration of the human body. Water is quickly absorbed by the digestive tract with a peak between 15 and 20 minutes. It has demonstrated that oral water remains the best hydration solution that have an effect on plasma volume expansion and cardiovascular system during exercise. While the cardiovascular effect of fluid expansion by saline serum is well known (venous return, preload and cardiac output), effect of oral water varies in the literature depending on the physiological state of the patient and the clinical state. Thus, the investigators aim to investigate oral water effects on fluid responsiveness, regional blood flow and microcirculatory changes.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

1. Comparison of oral water ingestion and intravenous fluid infusion on fluid responsiveness in healthy volunteers, a prospective, randomized trial.
   Huette P, Beyls C, Bayart G, Guinot PG, et al · · 2026 · PMID 41844879 · DOI 10.1038/s41598-026-43839-4