NCT05153395 is a EARLY_PHASE1 clinical trial of Carbon dioxide breathing in Healthy, sponsored by University of Missouri-Columbia.

Who is sponsoring NCT05153395?

NCT05153395 is sponsored by University of Missouri-Columbia.

What drugs are being tested in NCT05153395?

Interventions in NCT05153395: Carbon dioxide breathing, Neurovascular Coupling, Human insulin.

What condition does NCT05153395 study?

NCT05153395 studies Healthy, Vasodilation, Insulin Resistance, Autonomic Dysfunction, Obesity.

Is NCT05153395 still recruiting?

NCT05153395 is currently suspended. Last updated 12 December 2025.

Last reviewed 2025-12-12 · How we verify

NCT05153395

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Novel Treatment for Brain Insulin Resistance and Hypoperfusion

Suspended EARLY_PHASE1 Last updated 12 December 2025

What this trial tests

EARLY_PHASE1 trial testing Carbon dioxide breathing in Healthy in 65 participants. Suspended.

Timeline

1 December 2021

Primary endpoint
1 June 2027

1 June 2027

Quick facts

Lead sponsor	University of Missouri-Columbia
Phase	EARLY_PHASE1
Status	Suspended
Study type	INTERVENTIONAL
Allocation	non randomized
Design	parallel
Masking	none
Primary purpose	basic science
Enrollment	65
Start date	1 December 2021
Primary completion	1 June 2027
Estimated completion	1 June 2027
Sites	1 location across United States

Drugs / interventions tested

Carbon dioxide breathing
Neurovascular Coupling
Human insulin — full drug profile →

Conditions studied

Healthy — all drugs for Healthy →
Vasodilation — all drugs for Vasodilation →
Insulin Resistance — all drugs for Insulin Resistance →
Autonomic Dysfunction — all drugs for Autonomic Dysfunction →

Sponsor

University of Missouri-Columbia

Who can join

Adults 18 to 45, any sex, with Healthy or Vasodilation. Healthy volunteers can join.

What's being measured

Primary outcomes are the specific endpoints the trial is designed to prove or disprove.

Amount of cerebral blood flow
Time frame: Change from baseline at minute 15
Measured with trans-cranial Doppler ultrasound (cm/s) or arterial spin labeling (mL/100 g/min)

Sponsor's own description

The purpose of this project is to examine the impact of increases in brain insulin on sympathetic nervous system activity, as well as peripheral and cerebral blood flow in humans.

Publications & conference data

2 peer-reviewed publications reference this trial (live from Europe PMC):

Effect of acute intranasal insulin administration on muscle sympathetic nerve activity in healthy young adults.
McMillan NJ, Jacob DW, Shariffi B, Harper JL, et al · · 2024 · cited 5× · PMID 38787381 · DOI 10.1152/ajpheart.00253.2024
Effect of insulin on indices of cerebral blood flow and cerebrovascular compliance in young adults.
Shariffi B, Harper JL, McMillan NJ, Gonsalves AM, et al · · 2025 · cited 2× · PMID 39584591 · DOI 10.1152/ajpheart.00668.2024

Verify or expand the search:

Other recruiting trials for Healthy

Currently open trials in the same condition.

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Other University of Missouri-Columbia trials

Trials by the same sponsor.

NCT07478172 — Effects of Whole-body Electrical Muscle Stimulation Exercise on Adults With Neuromuscular Disease · NA · recruiting
NCT07385105 — Evaluation of Cognitive Behavioral Therapy for Insomnia (CBT-I) in Individuals With Mild Traumatic Brain Injury (mTBI) · NA · not yet recruiting
NCT07067502 — Impact of Biphasic Cuirass Ventilation Compared to Non Invasive Ventilation in High Risk Extubations · NA · not yet recruiting
NCT07424079 — Metacognitive Strategy Training Intervention for Transition-Age Youth With Cerebral Palsy · NA · not yet recruiting
NCT07216196 — The Feasibility of a Remote Problem-Solving Intervention for Autistic Adolescents or Young Adults and a Caregiver · NA · not yet recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT05153395 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by University of Missouri-Columbia
Last refreshed: 12 December 2025

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05153395.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing