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NCT05150418
Supplemental Oxygen in Hypovolemia
Phase 1 trial testing Oxygen gas in Hypovolemia in 15 participants. Completed in 14 June 2022.
14 June 2022
Quick facts
| Lead sponsor | Oslo University Hospital |
|---|---|
| Phase | Phase 1 |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | crossover |
| Masking | triple |
| Primary purpose | basic science |
| Enrollment | 15 |
| Start date | 26 November 2021 |
| Primary completion | 14 June 2022 |
| Estimated completion | 14 June 2022 |
| Sites | 1 location across Norway |
Drugs / interventions tested
- Oxygen gas — full drug profile →
- Air — full drug profile →
Conditions studied
- Hypovolemia — all drugs for Hypovolemia →
- Hyperoxia — all drugs for Hyperoxia →
Sponsor
Oslo University Hospital
Who can join
Adults 18 to 50, any sex, with Hypovolemia or Hyperoxia. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Supplemental oxygen is frequently administered in acutely and critically ill patients, specifically, it is often administered in trauma patients to avoid arterial hypoxemia and tissue hypoxia. There is also an increasing focus on potentially deleterious effects of hyperoxia. Further, the hemodynamic response to hyperoxia in hypovolemia is poorly understood. The present study aims to investigate the effects of supplemental oxygen on systemic and cerebral hemodynamics in simulated hypovolemia in healthy volunteers.
Publications & conference data
2 peer-reviewed publications reference this trial (live from Europe PMC):
-
Hemodynamic effects of supplemental oxygen versus air in simulated blood loss in healthy volunteers: a randomized, controlled, double-blind, crossover trial.
Lie SL, Hisdal J, Rehn M, Høiseth LØ. · · 2023 · cited 3× · PMID 37947905 · DOI 10.1186/s40635-023-00561-z -
London Trauma Conference December 2022: Abstracts
· 2023
Verify or expand the search:
- PubMed search for NCT05150418
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Other Oslo University Hospital trials
Trials by the same sponsor.
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT05150418 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Oslo University Hospital
- Last refreshed: 5 July 2022
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05150418.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing