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NCT05149833: E-StOIC
European Study of Opioid Induced Constipation
trial in Opioid-Induced Constipation in 1,200 participants. Completed in 31 July 2024.
31 July 2024
Quick facts
| Lead sponsor | University of Dublin, Trinity College |
|---|---|
| Status | Completed |
| Study type | OBSERVATIONAL |
| Enrollment | 1,200 |
| Start date | 16 September 2021 |
| Primary completion | 31 July 2024 |
| Estimated completion | 31 July 2024 |
| Sites | 1 location across Ireland |
Conditions studied
- Opioid-Induced Constipation — all drugs for Opioid-Induced Constipation →
Sponsor
University of Dublin, Trinity College
Who can join
18 and older, any sex, with Opioid-Induced Constipation. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Constipation is common (40-90%) in advanced cancer patients , and has a significant negative impact on quality of life. The aetiology of constipation is often multifactorial in advanced cancer patients. However, it is well recognised that opioid analgesics are a common cause of constipation in this group. The prevalence of opioid-induced constipation (OIC) is stated to be 40-70%, although a recent large study reported an even higher figure. OIC has been reported to exceed pain in terms of distress caused, and studies have found that some patients choose to reduce or discontinue opioid medication in order to attempt to better control constipation. Moreover, OIC is associated with a variety of physical (gastrointestinal, systemic), psychological and social problems.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
'Constipation': One word, many meanings amongst persons with cancer: An observational study.
Davies A, Fagan N, Power J, Taylor A. · · 2025 · cited 1× · PMID 40071858 · DOI 10.1177/02692163251325711
Verify or expand the search:
- PubMed search for NCT05149833
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT05149833 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by University of Dublin, Trinity College
- Last refreshed: 3 April 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05149833.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing