NCT05148468 is a NA clinical trial of Active spinal cord stimulation in Parkinson Disease, sponsored by University of Sao Paulo General Hospital.

Who is sponsoring NCT05148468?

NCT05148468 is sponsored by University of Sao Paulo General Hospital.

What drugs are being tested in NCT05148468?

Interventions in NCT05148468: Active spinal cord stimulation, Sham spinal cord stimulation.

What condition does NCT05148468 study?

NCT05148468 studies Parkinson Disease, Gait Disorders, Neurologic.

Is NCT05148468 still recruiting?

NCT05148468 is currently terminated. Last updated 13 May 2024.

Last reviewed 2024-05-13 · How we verify

NCT05148468

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Effects of Spinal Cord Stimulation on Gait in Patients With Parkinson´s Disease

Terminated NA Last updated 13 May 2024

What this trial tests

NA trial testing Active spinal cord stimulation in Parkinson Disease in 8 participants. Terminated before completion.

Timeline

30 November 2021

Primary endpoint
10 January 2024

1 March 2024

Quick facts

Lead sponsor	University of Sao Paulo General Hospital
Phase	NA
Status	Terminated
Study type	INTERVENTIONAL
Allocation	randomized
Design	crossover
Masking	quadruple
Primary purpose	treatment
Enrollment	8
Start date	30 November 2021
Primary completion	10 January 2024
Estimated completion	1 March 2024
Sites	1 location across Brazil

Drugs / interventions tested

Active spinal cord stimulation
Sham spinal cord stimulation

Conditions studied

Parkinson Disease — all drugs for Parkinson Disease →
Gait Disorders, Neurologic — all drugs for Gait Disorders, Neurologic →

Sponsor

University of Sao Paulo General Hospital

Who can join

Adults 21 to 80, any sex, with Parkinson Disease or Gait Disorders, Neurologic. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Spinal cord stimulation (SCS) for Parkinson´s disease (PD) has been studied for a decade but consensus on efficacy is still lacking, with the previous stimulation standard paresthesia inducing threshold hampering adequate subject blinding. Considering that tonic stimulation for pain has been shown to be efficacious for most patients on subthreshold stimulation parameters we hypothesize a similar result with it´s use on PD. The investigators aim to: 1. Produce stronger evidence on SCS efficacy for PD in regards to gait, motor scores and quality of life measures by incorporating subthreshold in a randomized cross over placebo-controlled study with a large sample. 2. Identify predictors of good response to SCS therapy by performing trans spinal magnetic stimulation (TSMS) before SCS implant and correlating the response to SCS to that of the noninvasive TSMS. 3. Better provide biomarkers of SCS therapy through functional magnetic resonance imaging and electroencephalographic mapping.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

A Pragmatic Review on Spinal Cord Stimulation Therapy for Parkinson's Disease Gait Related Disorders: Gaps and Controversies.
Hvingelby VS, Carra RB, Terkelsen MH, Hamani C, et al · · 2024 · cited 5× · PMID 38899557 · DOI 10.1002/mdc3.14143

Verify or expand the search:

Other recruiting trials for Parkinson Disease

Currently open trials in the same condition.

NCT07399496 — Accelerated TMS for Apathy in PD · NA · recruiting
NCT07371338 — Phase 1 Clinical Trial to Evaluate the Safety, Efficacy, and Pharmacokinetics of IPS101A in Parkinson's Disease Patients · Phase 1 · recruiting
NCT07442370 — The Effect of Functional Rotational Exercises on Fall Risk and Mobility in Parkinson's Disease Patients · NA · recruiting
NCT06848205 — Percept Transitions in FOG and PD · NA · recruiting
NCT07432958 — A Study to Evaluate the Effectiveness of Two Doses of AP-472 as Adjunctive Therapy to Levodopa in Parkinson's Disease (P · Phase 2 · recruiting

Other University of Sao Paulo General Hospital trials

Trials by the same sponsor.

NCT07275580 — Antibiotic Prophylaxis After Simple Tooth Extraction in Immunosuppressed Patients With Autoimmune Rheumatic Diseases · Phase 4 · not yet recruiting
NCT07478094 — Longitudinal Outcomes of Patients With Group 3 Pulmonary Hypertension Treated With Iloprost · not yet recruiting
NCT07341386 — Prevention of Recurrence of Herpes Simplex in Autoimmune Rheumatic Diseases · Phase 4 · not yet recruiting
NCT07242092 — Influence of Methotrexate Discontinuation on Immunogenicity After PCV-20 Vaccine in Patients ARDs · Phase 4 · not yet recruiting
NCT07484152 — Motor and Non-Motor Effects of Low-Intensity Focused Ultrasound (LIFU) as a Neuromodulation Tool in Essential Tremor · Phase 1, PHASE2 · not yet recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT05148468 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by University of Sao Paulo General Hospital
Last refreshed: 13 May 2024

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05148468.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing