Who is sponsoring NCT05147636?

NCT05147636 is sponsored by Centre Hospitalier de Bourg en Bresse.

What drugs are being tested in NCT05147636?

Interventions in NCT05147636: Extubation with PEEP, Endotracheal Aspiration.

What condition does NCT05147636 study?

NCT05147636 studies Extubation in Intensive Care Unit.

Is NCT05147636 still recruiting?

NCT05147636 is currently completed. Last updated 5 December 2025.

Last reviewed 2025-12-05 · How we verify

NCT05147636: EXSUPEEP

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

EXtubation With SUctioning or With Positive End-Expiratory Pressure in Intensive Care Unit

Completed NA Last updated 5 December 2025

What this trial tests

NA trial testing Extubation with PEEP in Extubation in Intensive Care Unit in 425 participants. Completed in 19 March 2025.

Timeline

22 March 2023

Primary endpoint
19 March 2025

19 March 2025

Quick facts

Lead sponsor	Centre Hospitalier de Bourg en Bresse
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	none
Primary purpose	supportive care
Enrollment	425
Start date	22 March 2023
Primary completion	19 March 2025
Estimated completion	19 March 2025
Sites	11 locations across France

Drugs / interventions tested

Extubation with PEEP
Endotracheal Aspiration

Conditions studied

Extubation in Intensive Care Unit — all drugs for Extubation in Intensive Care Unit →

Sponsor

Centre Hospitalier de Bourg en Bresse

Who can join

18 and older, any sex, with Extubation in Intensive Care Unit. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Extubation in intensive care unit is a risky situation. Its failure is associated with an increase in the duration of mechanical ventilation and high morbidity and mortality. Our hypothesis is that the extubation procedure associating prior endotracheal aspiration followed by ablation of the intubation probe under the application of a PEEP, would make it possible both to avoid the leakage of secretions towards the lower airways and the alveolar recruitment, compared to extubation with concomitant endotracheal aspiration. By these mechanisms, this extubation procedure combining prior endotracheal aspiration followed by ablation of the tube under the application of a PEEP, would make it possible to increase the ventilator free days from any mechanical ventilation.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

Applying positive end-expiratory pressure before and during endotracheal tube removal versus extubation with concomitant aspiration: protocol for the randomised controlled multicentre EXSUPEEP trial.
Sedillot N, Kallel H, Robine A, Pineda JA, et al · · 2025 · PMID 39947817 · DOI 10.1136/bmjopen-2024-092354

Verify or expand the search:

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT05147636 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Centre Hospitalier de Bourg en Bresse
Last refreshed: 5 December 2025

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05147636.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing