NCT05144022

Multi-level Molecular Profiling of High Acute Stress: a Clinical Study

Status unknown NA Last updated 10 November 2022

What this trial tests

NA trial testing Bungee jump in Healthy in 35 participants. Status unknown.

Timeline

1 September 2021

Primary endpoint
1 January 2022

1 January 2023

Quick facts

Lead sponsor	University Hospital, Bonn
Phase	NA
Status	Status unknown
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	none
Primary purpose	basic science
Enrollment	35
Start date	1 September 2021
Primary completion	1 January 2022
Estimated completion	1 January 2023
Sites	1 location across Germany

Drugs / interventions tested

• Bungee jump

Conditions studied

• Healthy — all drugs for Healthy →

Sponsor

University Hospital, Bonn

Who can join

Adults 20 to 40, male only, with Healthy. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Although it is well known that stress plays an important role in the development of neuropsychiatric diseases, the precise role and molecular effects of stress have only been poorly understood. For example, autophagy is essential for energy and cellular homeostasis through protein catabolism, and dysregulation results in compromised proteostasis, stress-coping behavior, and excessive secretion of signaling molecules and inflammatory factors. Therefore, the aim of the project is to analyze the clinical effects of a bungee jump resembling an acute stress event in correlation to autophagy and other underlying, multi-level molecular profiling. Specifically, it is planned to perform multi-level molecular profiling and sleep analysis in a cohort of healthy male individuals before, during, and after a bungee jump compared to a control cohort of healthy males not undergoing a stress event. The resulting findings will advance the role of autophagy during the stress response and hence in the development of psychiatric disorders, and possibly investigate alternative treatment venues on a molecular level, and finally contribute to a better clinical outcome.

Publications & conference data

No peer-reviewed publications indexed yet for this trial.