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NCT05142215: ORBITA-CTO
A Placebo-controlled Trial of Chronic Total Occlusion Percutaneous Coronary Intervention for the Relief of Stable Angina
Completed
NA
Last updated 20 November 2025
What this trial tests
NA trial testing Percutaneous coronary intervention in Stable Angina in 50 participants. Completed in 21 October 2025.
Timeline
19 October 2021
Primary endpoint
21 October 2025
21 October 2025
21 October 2025
Quick facts
| Lead sponsor | Mid and South Essex NHS Foundation Trust |
|---|---|
| Phase | NA |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | quadruple |
| Primary purpose | treatment |
| Enrollment | 50 |
| Start date | 19 October 2021 |
| Primary completion | 21 October 2025 |
| Estimated completion | 21 October 2025 |
| Sites | 3 locations across United Kingdom |
Drugs / interventions tested
- Percutaneous coronary intervention
- Placebo percutaneous coronary intervention
Conditions studied
- Stable Angina — all drugs for Stable Angina →
- Chronic Total Occlusion of Coronary Artery — all drugs for Chronic Total Occlusion of Coronary Artery →
Sponsor
Mid and South Essex NHS Foundation Trust
Who can join
18 and older, any sex, with Stable Angina or Chronic Total Occlusion of Coronary Artery. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
ORBITA-CTO Pilot is a double blinded randomised placebo-controlled trial comparing the effects of chronic total occlusion percutaneous coronary intervention versus placebo on symptoms of angina in patients with background optimal medical therapy.
Publications & conference data
7 peer-reviewed publications reference this trial (live from Europe PMC):
-
Ten-Year Outcome of Recanalization or Medical Therapy for Concomitant Chronic Total Occlusion After Myocardial Infarction.
van Veelen A, Coerkamp CF, Somsen YBO, Råmunddal T, et al · · 2024 · cited 8× · PMID 38726918 · DOI 10.1161/jaha.123.033556 -
The challenges of a randomised placebo-controlled trial of CTO PCI vs. placebo with optimal medical therapy: The ORBITA-CTO pilot study design and protocol.
Khan S, Fawaz S, Simpson R, Robertson C, et al · · 2023 · cited 8× · PMID 37206100 · DOI 10.3389/fcvm.2023.1172763 -
Percutaneous Coronary Intervention for Chronic Total Occlusion-Contemporary Approach and Future Directions.
Dąbrowski EJ, Święczkowski M, Dudzik JM, Grunwald O, et al · · 2023 · cited 7× · PMID 37297958 · DOI 10.3390/jcm12113762 -
Shared Experiences With Guidewire Application in Chronic Total Occlusion: Technological Advances and Clinical Implications.
Liu D, Zhi Y, Sun W, Ma Y, et al · · 2025 · cited 1× · PMID 40776950 · DOI 10.31083/rcm33469 -
Coronary Chronic Total Occlusion Revascularization: When, Who and How?
Ricottini E, Coletti F, Nusca A, Cocco N, et al · · 2024 · cited 1× · PMID 38610708 · DOI 10.3390/jcm13071943 -
Reconsidering the evidence for CTO PCI: the devil is in the detail.
Al-Lamee RK, Khan SA, Davies J. · · 2023 · cited 1× · PMID 37720966 · DOI 10.4244/eij-e-23-00040 -
Randomized, Placebo-Controlled Trial of Chronic Total Occlusion Percutaneous Coronary Intervention in Stable Angina: The ORBITA-CTO Trial.
Khan S, Sajjad U, Fawaz S, Butt H, et al · · 2026 · PMID 41999379 · DOI 10.1016/j.jacc.2026.03.027
Verify or expand the search:
- PubMed search for NCT05142215
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Other recruiting trials for Stable Angina
Currently open trials in the same condition.
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Other Mid and South Essex NHS Foundation Trust trials
Trials by the same sponsor.
- NCT06702306 — Duplex UltraSound afTer Endo Revascularisation - Feasibility Randomised Control Trial (DUSTER) · NA · active not recruiting
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
Data sources for this page
- Trial protocol + status: ClinicalTrials.gov NCT05142215 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Mid and South Essex NHS Foundation Trust
- Last refreshed: 20 November 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05142215.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing