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NCT05141227
Two-stage ORIF Vs Ex. Fix. in Complex Pilon Fractures
NA trial testing Two-stage Open reduction and internal fixation ( ORIF) using plates & screws in Pilon Fracture in 60 participants. Completed in 1 February 2024.
15 December 2023
Quick facts
| Lead sponsor | Ain Shams University |
|---|---|
| Phase | NA |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | none |
| Primary purpose | treatment |
| Enrollment | 60 |
| Start date | 1 December 2021 |
| Primary completion | 15 December 2023 |
| Estimated completion | 1 February 2024 |
| Sites | 1 location across Egypt |
Drugs / interventions tested
- Two-stage Open reduction and internal fixation ( ORIF) using plates & screws
- single-stage external fixation (EX.FIX.) with minimal internal fixation using cannulated screws if needed
Conditions studied
- Pilon Fracture — all drugs for Pilon Fracture →
Sponsor
Ain Shams University
Who can join
18 and older, any sex, with Pilon Fracture. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
This study aims to compare the clinical, radiological, and functional outcomes of two-stage open reduction and internal fixation with single-stage external fixation in the treatment of comminuted tibial pilon fractures.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Comparison of two-stage open reduction and internal fixation and single-stage external fixation for complex pilon fractures: a randomized controlled trial.
Eissa MO, Thakeb MF, AbouSeif S, Fayyad TA, et al · · 2026 · PMID 41225168 · DOI 10.1007/s00264-025-06682-2
Verify or expand the search:
- PubMed search for NCT05141227
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other recruiting trials for Pilon Fracture
Currently open trials in the same condition.
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Other Ain Shams University trials
Trials by the same sponsor.
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT05141227 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Ain Shams University
- Last refreshed: 9 April 2024
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05141227.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing