Last reviewed · How we verify
NCT05140642: EchoNet-RCT
Safety and Efficacy Study of AI LVEF
NA trial testing Automated annotation of the left ventricle through deep learning in Heart Failure, Systolic in 3,495 participants. Completed in 29 June 2022.
29 June 2022
Quick facts
| Lead sponsor | Cedars-Sinai Medical Center |
|---|---|
| Phase | NA |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | single group |
| Masking | single |
| Primary purpose | diagnostic |
| Enrollment | 3,495 |
| Start date | 1 April 2022 |
| Primary completion | 29 June 2022 |
| Estimated completion | 29 June 2022 |
| Sites | 1 location across United States |
Drugs / interventions tested
- Automated annotation of the left ventricle through deep learning
- Sonographer Measurement of LVEF
Conditions studied
- Heart Failure, Systolic — all drugs for Heart Failure, Systolic →
- Heart Failure, Diastolic — all drugs for Heart Failure, Diastolic →
Sponsor
Cedars-Sinai Medical Center
Who can join
Adults 18 to 110, any sex, with Heart Failure, Systolic or Heart Failure, Diastolic. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
To determine whether an integrated AI decision support can save time and improve accuracy of assessment of echocardiograms, the investigators are conducting a blinded, randomized controlled study of AI guided measurements of left ventricular ejection fraction compared to sonographer measurements in preliminary readings of echocardiograms.
Publications & conference data
2 peer-reviewed publications reference this trial (live from Europe PMC):
-
Blinded, randomized trial of sonographer versus AI cardiac function assessment.
He B, Kwan AC, Cho JH, Yuan N, et al · · 2023 · cited 170× · PMID 37020027 · DOI 10.1038/s41586-023-05947-3 -
A cardiologist's guide to machine learning in cardiovascular disease prognosis prediction.
Kresoja KP, Unterhuber M, Wachter R, Thiele H, et al · · 2023 · cited 23× · PMID 36939941 · DOI 10.1007/s00395-023-00982-7
Verify or expand the search:
- PubMed search for NCT05140642
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other recruiting trials for Heart Failure, Systolic
Currently open trials in the same condition.
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- NCT06675552 — Non-interventional Study on Guideline Directed Medical Therapy for Patients With Heart Failure (HF) in Germany · recruiting
- NCT06332391 — Paced Heart Rate Acceleration for Cardiac Conditioning · NA · recruiting
- NCT05632432 — Atrial Appendage Micrograft Transplants to Assist Heart Repair After Cardiac Surgery · NA · recruiting
Other Cedars-Sinai Medical Center trials
Trials by the same sponsor.
- NCT06012487 — Correlates and Control of Blood Pressure Variability · Phase 1 · not yet recruiting
- NCT07495995 — SAMe for Prevention of Liver Cancer in MASLD-Related Cirrhosis · Phase 2 · not yet recruiting
- NCT07413965 — TAVR vs SAVR in Severe Bicuspid Aortic Stenosis · NA · not yet recruiting
- NCT06521021 — CHOICE to AVOID or RESIST · NA · not yet recruiting
- NCT07499089 — Together-Breast Cancer Support Platform · not yet recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT05140642 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Cedars-Sinai Medical Center
- Last refreshed: 5 July 2022
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05140642.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing