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Study on Precision Treatment of Diabetic Retinopathy Macular Edema Guided by Real-time Optical Coherence Tomography During Operation
Select Proliferative Proliferative diabetic retinopathy(PDR) patients who are planning to undergo vitrectomy for informed notification. After obtaining informed consent, vitrectomy will be performed. After hemorrhage is removed, the macular shape can be obtained through intraoperative optical coherence tomography (iOCT) real-time scanning. If the central Macular Thickness (CMT) of the patient is ≥250μm, random Enter the Anti-vascular endothelial growth factor (anti-VEGF) treatment group, the internal limiting membrane stripping group and the glucocorticoid treatment group for treatment, and compare the patients' visual acuity (1 day, 7 days, 1 month, 3 months, 6 months) and The thickness of the center of the macula, compare and observe its treatment effect.
Details
| Lead sponsor | Affiliated Hospital of Nantong University |
|---|---|
| Phase | Phase 3 |
| Status | UNKNOWN |
| Enrolment | 60 |
| Start date | 2021-11-15 |
| Completion | 2024-05 |
Conditions
- Diabetic Retinopathy
Interventions
- Ranibizumab Injection [Lucentis]
- Inner limiting membrane stripping
- Dexamethasone intravitreal implant
Primary outcomes
- Review the patient's vision before surgery — The day before the patient's surgery
Optical Coherence Tomography (OCT) is currently the main examination method for measuring retinal thickness and evaluating DME morphology and fine structure. DME OCT examination has a variety of morphological manifestations and accompanying images, and various manifestations reflect different pathological basis.
Countries
China