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NCT05134246: CRICS
Carotid Revascularization for Radiation Induced Carotid Artery Stenosis
trial testing Carotid endarterectomy (CEA) in Radiation-induced Carotid Artery Stenosis in 150 participants. Currently enrolling.
31 December 2026
Quick facts
| Lead sponsor | Xuanwu Hospital, Beijing |
|---|---|
| Status | Recruiting now |
| Study type | OBSERVATIONAL |
| Enrollment | 150 |
| Start date | 5 January 2020 |
| Primary completion | 31 December 2026 |
| Estimated completion | 31 December 2027 |
| Sites | 2 locations across China |
Drugs / interventions tested
- Carotid endarterectomy (CEA)
- Carotid artery stenting (CAS)
Conditions studied
- Radiation-induced Carotid Artery Stenosis — all drugs for Radiation-induced Carotid Artery Stenosis →
Sponsor
Xuanwu Hospital, Beijing
Who can join
18 and older, any sex, with Radiation-induced Carotid Artery Stenosis. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Cervical radiotherapy (RT) has greatly reduced the mortality of patients with malignant head and neck tumors, which, however, causes a higher risk of carotid artery stenosis, namely, radiation-induced carotid artery stenosis (RICS) and results in a significant increased risk of ischemic stroke. The systematic review and meta-analysis conducted by our team showed carotid endarterectomy (CEA) can yield better results for these patients than carotid artery stenting (CAS), which was contrary to most previous clinical guidelines. A large-scale prospective study is needed to verify the results. We will conduct a prospective registry of RICS patients treated with CEA to evaluate both short-term safety and long-term efficacy outcomes in a Chinese population.
Publications & conference data
No peer-reviewed publications indexed yet for this trial.
Verify or expand the search:
- PubMed search for NCT05134246
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
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Trials testing the same drug.
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- NCT05296876 — SSPC Evaluation on Carotid Artery Stenosis After Endarterectomy · unknown
- NCT02089217 — Carotid Revascularization and Medical Management for Asymptomatic Carotid Stenosis Trial · NA · completed
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT05134246 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Xuanwu Hospital, Beijing
- Last refreshed: 3 March 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05134246.
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