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Transforaminal Epidural Platelet Rich Plasma Versus Epidural Steroid Injection for Lumbosacral Radicular Pain: a Randomized Controlled Trial
Lumbosacral radicular pain is present in around 40% of cases of low back pain. It is usually caused by irritation and inflammation of the nerve root, and patients typically experience pain radiating from the back to the lower limb in the distribution of the affected spinal nerves. Epidural steroid injection is the most commonly used pain-relieving procedure in the world. However, the analgesic efficacy of epidural steroid injection appears to be modest and duration limited. Platelet rich plasma (PRP) is an emerging treatment option for chronic pain. It is currently used for treating musculoskeletal pain conditions such as osteoarthritis and tendinopathies. While epidural steroids reduce pain by reducing inflammation, PRP promotes the healing of nerve injury and reduces neuropathic pain. However, the effect of transforaminal epidural PRP versus epidural steroid specifically for lumbosacral radicular pain is unclear. In this study, a double blind, randomized controlled trial will be performed to compare the effect of transforaminal epidural PRP versus epidural steroid for pain relief in patients with lumbosacral radicular pain.
Details
| Lead sponsor | The University of Hong Kong |
|---|---|
| Phase | Phase 4 |
| Status | UNKNOWN |
| Enrolment | 70 |
| Start date | 2021-03-01 |
| Completion | 2024-12 |
Conditions
- Chronic Pain
Interventions
- Dexamethasone 4mg
- epidural platelet rich plasma injection
Primary outcomes
- Pain Score at rest — at postoperative day 1
Pain at rest assessed by numerical rating scales (NRS) from 0 to 10, where 0 = the least pain and 10 = the worst pain.
Countries
Hong Kong