Last reviewed · How we verify
NCT05128188: SASH
SASH: Sodium Accumulation Study In Haemodialysis
trial testing No intervention will be given in this study in Haemodialysis in 10 participants. Completed in 2 September 2023.
2 August 2023
Quick facts
| Lead sponsor | University Hospitals of Derby and Burton NHS Foundation Trust |
|---|---|
| Status | Completed |
| Study type | OBSERVATIONAL |
| Enrollment | 10 |
| Start date | 1 March 2022 |
| Primary completion | 2 August 2023 |
| Estimated completion | 2 September 2023 |
| Sites | 1 location across United Kingdom |
Drugs / interventions tested
- No intervention will be given in this study
Conditions studied
- Haemodialysis — all drugs for Haemodialysis →
- End Stage Renal Disease on Dialysis — all drugs for End Stage Renal Disease on Dialysis →
Sponsor
University Hospitals of Derby and Burton NHS Foundation Trust
Who can join
Adults 50 to 75, male only, with Haemodialysis or End Stage Renal Disease on Dialysis. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Haemodialysis (HD) sustains life in patients with end-stage kidney disease (ESKD) but is associated with a marked increase in incidence of cardiovascular disease (CVD) and high annual mortality rates. The pathogenesis of CVD in patients on HD is multifactorial and complex but hypertension is thought to be a major contributing factor. Sodium balance is normally regulated by the kidneys in health but has to be achieved by sodium removal during HD for those with ESKD. Recent evidence suggests that accumulation of sodium in the skin and / or muscle may be a critical factor impacting the development of hypertension and CVD in patients with ESKD and non-invasive methods are therefore required to study tissue sodium accumulation in this context. This study aims to determine the change in skin and muscle sodium content in patients undergoing haemodialysis. Participants will have a single haemodialysis session, and undergo two MRI scans (one prior to and one following dialysis).
Publications & conference data
No peer-reviewed publications indexed yet for this trial. Completed trials usually publish results within 12-18 months.
Verify or expand the search:
- PubMed search for NCT05128188
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other recruiting trials for Haemodialysis
Currently open trials in the same condition.
- NCT07427264 — The Effect of a Mixed-type Intradialytic Exercise Training Program on Body Composition, Functional Capacity, and Muscle · NA · active not recruiting
- NCT06641765 — Continuous Glucose Monitoring in Dialysis Patients With Diabetes · NA · active not recruiting
- NCT06225544 — Lumasiran in Hyperoxalaemic Patients on Haemodialysis · Phase 2 · recruiting
- NCT04842591 — Characteristics of Pulmonary Vascular Changes in Patients With Kidney Transplantation · active not recruiting
Other University Hospitals of Derby and Burton NHS Foundation Trust trials
Trials by the same sponsor.
- NCT07377500 — Dialysate Cooling for the Preservation of Cognitive Function in People Receiving Haemodialysis · NA · not yet recruiting
- NCT07205692 — Multimorbidity and Cardiovascular Risk Factors After Renal Transplant · recruiting
- NCT06109662 — Multimorbidity and Sarcopenia Feasibility Study in Chronic Kidney Disease · active not recruiting
- NCT06259305 — Memories in Heartbeats Study · NA · completed
- NCT06284044 — Facilitating Safe Transition to Home for Preterm Infants - a National Database Study · completed
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT05128188 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by University Hospitals of Derby and Burton NHS Foundation Trust
- Last refreshed: 9 August 2024
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05128188.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing