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NCT05127369
Clinical Study on the Safety and Efficacy of Dental Pulp Mesenchymal Cells in the Treatment of Depression
NA trial testing Dental pulp mesenchymal cell injection in Depression in 48 participants. Status unknown.
30 December 2023
Quick facts
| Lead sponsor | CAR-T (Shanghai) Biotechnology Co., Ltd. |
|---|---|
| Phase | NA |
| Status | Status unknown |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | single |
| Primary purpose | treatment |
| Enrollment | 48 |
| Start date | 1 January 2022 |
| Primary completion | 30 December 2023 |
| Estimated completion | 30 June 2024 |
Drugs / interventions tested
- Dental pulp mesenchymal cell injection — full drug profile →
- Dental pulp mesenchymal cell vehicle — full drug profile →
- fluoxetine hydrochloride capsule
Conditions studied
- Depression — all drugs for Depression →
Sponsor
CAR-T (Shanghai) Biotechnology Co., Ltd. — full company profile →
Who can join
Adults 18 to 60, any sex, with Depression. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
This is a single center phase I / II clinical trial. Randomized, blind and positive drug parallel control were used to evaluate the safety and effectiveness of dental pulp mesenchymal cell injection in the treatment of depression 8 weeks after administration
Publications & conference data
2 peer-reviewed publications reference this trial (live from Europe PMC):
-
Mesenchymal Stromal Cells Derived from Dental Tissues: Immunomodulatory Properties and Clinical Potential.
Poblano-Pérez LI, Castro-Manrreza ME, González-Alva P, Fajardo-Orduña GR, et al · · 2024 · cited 13× · PMID 38396665 · DOI 10.3390/ijms25041986 -
Research progress on optimization of <i>in vitro</i> isolation, cultivation and preservation methods of dental pulp stem cells for clinical application.
Wang X, Li F, Wu S, Xing W, et al · · 2024 · cited 6× · PMID 38633667 · DOI 10.3389/fbioe.2024.1305614
Verify or expand the search:
- PubMed search for NCT05127369
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Other CAR-T (Shanghai) Biotechnology Co., Ltd. trials
Trials by the same sponsor.
- NCT04302519 — Novel Coronavirus Induced Severe Pneumonia Treated by Dental Pulp Mesenchymal Stem Cells · EARLY_PHASE1 · unknown
- NCT04130100 — Clinical Study of Pulp Mesenchymal Stem Cells in the Treatment of Primary Mild to Moderate Knee Osteoarthritis · EARLY_PHASE1 · unknown
- NCT03912480 — Stem Cells From Human Exfoliated Teeth in Treatment of Diabetic Patients With Significantly Reduced Islet Function · EARLY_PHASE1 · unknown
- NCT03658655 — Stem Cells From Human Exfoliated Teeth in Treatment of Type 2 Diabetes · EARLY_PHASE1 · completed
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT05127369 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 9 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by CAR-T (Shanghai) Biotechnology Co., Ltd.
- Last refreshed: 19 November 2021
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05127369.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing