Who is sponsoring NCT05127018?

NCT05127018 is sponsored by Peking University.

What condition does NCT05127018 study?

NCT05127018 studies Smiling, Botulinum Toxins, Type A.

What drugs are being tested in NCT05127018?

Interventions: injection of Botulinum type A.

What is the status of NCT05127018?

NCT05127018 is currently COMPLETED.

Last reviewed 2023-04-26 · How we verify

Higher Doses of Botulinum Toxin in the Treatment of Gummy Smile

NCT05127018 PHASE1, PHASE2 COMPLETED Results posted

Botulinum type A (BTX-A) is an easy and efficacious treatment for gingival smile (GS). However, the necessary for higher-doses among patients are controversial. The objective was to compare the reduction of gingival exposure using two methods in patients with different dosage. In this prospective self-controlled study, healthy GS participates who had an anterior gingival exposure (GE) of more than 3 mm were enrolled and administered with 2-5 U BTX-A (total, 4-10 U) injections into 1-2 points according to the severity presented pretreatment in the Average-dose Method. And after 8 months, the Higher-doses Method was administered the same point injection of 3-10 U BTX-A (total, 6-20 U). Data were collected at baseline and 4, 12, 32 and 60 weeks of follow-up.

Details

Lead sponsor	Peking University
Phase	PHASE1, PHASE2
Status	COMPLETED
Enrolment	33
Start date	Wed Nov 20 2019 00:00:00 GMT+0000 (Coordinated Universal Time)
Completion	Wed Oct 20 2021 00:00:00 GMT+0000 (Coordinated Universal Time)

Conditions

Smiling
Botulinum Toxins, Type A

Interventions

injection of Botulinum type A

Countries

China