NCT05125133: ITENs

Evaluation of Insecticide-treated Eave Nets and Window Screens for Malaria Control in Tanzania.

Status unknown NA Last updated 2 December 2021

What this trial tests

NA trial testing ITENs + ITWS in Malaria,Falciparum in 1,800 participants. Status unknown.

Timeline

9 July 2021

Primary endpoint
31 August 2022

30 September 2022

Quick facts

Lead sponsor	Ifakara Health Institute
Phase	NA
Status	Status unknown
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	none
Primary purpose	prevention
Enrollment	1,800
Start date	9 July 2021
Primary completion	31 August 2022
Estimated completion	30 September 2022
Sites	1 location across Tanzania

Drugs / interventions tested

• ITENs + ITWS

Conditions studied

• Malaria,Falciparum — all drugs for Malaria,Falciparum →

Sponsor

Ifakara Health Institute

Who can join

6 Months and older, any sex, with Malaria,Falciparum. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

This is a household randomized trial of a new tool for house modification, Insecticide-Treated Eave nets (ITENs) in combination with insecticide-treated window screens (ITWS), coated with a dual active ingredient (dual AI): Deltamethrin at 3g AI/kg, which corresponds to 144 mg/m² and PBO synergist at 10g/kg which corresponds to 480 mg/m², as used in the so-called dual-AI LLIN or "resistance breaking" nets for resistance malaria vector control.

Four hundred and fifty (450) households with intact walls, opened eaves, and those without screens or nets on the windows in Chalinze district, Tanzania will be eligible and only recruited upon written informed consent. The households will be randomly allocated into two arms: one with ITENs and ITWS installed and the other without.

The primary outcome will be malaria parasite detection in household residents aged over 6 months old using a quantitative Polymerase Chain Reaction (qPCR) at approximately 12 months post-installation, coinciding with the long rainy season.

Publications & conference data

3 peer-reviewed publications reference this trial (live from Europe PMC):

1. Insecticide-treated eave nets and window screens for malaria control in Chalinze district, Tanzania: a study protocol for a household randomised control trial.
   Odufuwa OG, Moore SJ, Mboma ZM, Mbuba E, et al · · 2022 · cited 6× · PMID 35854371 · DOI 10.1186/s13063-022-06408-4
2. A household randomized-control trial of insecticide-treated screening for malaria control in unimproved houses in Tanzania.
   Odufuwa OG, Moore SJ, Mboma ZM, Mwanga R, et al · · 2025 · PMID 40484966 · DOI 10.1186/s12936-025-05434-2
3. A household randomised-control trial of insecticide-treated screening for malarial control in unimproved houses in Tanzania
   Odufuwa OG, Moore SJ, Mboma ZM, Mwanga R, et al · · 2025 · DOI 10.21203/rs.3.rs-6218916/v1