Last reviewed · How we verify
NCT05124132: MEDEX-2
Resilience and Brain Health of Older Adults (MEDEX-2)
NA trial testing Mindfulness-Based Stress Reduction in Age-related Cognitive Decline in 468 participants. Enrolling by invitation.
31 August 2026
Quick facts
| Lead sponsor | Washington University School of Medicine |
|---|---|
| Phase | NA |
| Status | ENROLLING BY INVITATION |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | factorial |
| Masking | single |
| Primary purpose | treatment |
| Enrollment | 468 |
| Start date | 16 April 2019 |
| Primary completion | 31 August 2026 |
| Estimated completion | 31 August 2026 |
| Sites | 1 location across United States |
Drugs / interventions tested
- Mindfulness-Based Stress Reduction
- Exercise
- Mindfulness-Based Stress Reduction + Exercise
- Health Education
Conditions studied
- Age-related Cognitive Decline — all drugs for Age-related Cognitive Decline →
Sponsor
Washington University School of Medicine
Who can join
65 and older, any sex, with Age-related Cognitive Decline. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
This project capitalizes on a natural experiment imposed by the COVID-19 pandemic in conjunction with an extensive set of cognitive, emotional, biological, and neuroimaging variables already collected at multiple time points in older adults participating in a clinical trial of exercise and mindfulness. This project will elucidate the effects of stress on cognitive function and emotional health in later life, including biological measures of Alzheimer Disease risk, stress, and aging, with the ultimate goal of discovering how to mitigate these effects, among older adults who have made and maintained a lifestyle change.
Publications & conference data
No peer-reviewed publications indexed yet for this trial.
Verify or expand the search:
- PubMed search for NCT05124132
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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- NCT05516355 — Psychological and Neurobiological Impact of a Retreat Based on Mindfulness and Compassion for Stress Reduction. · NA · completed
- NCT04977245 — Mindfulness-Based Stress Reduction in Dementia Caregivers · NA · completed
Other recruiting trials for Age-related Cognitive Decline
Currently open trials in the same condition.
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Other Washington University School of Medicine trials
Trials by the same sponsor.
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT05124132 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Washington University School of Medicine
- Last refreshed: 18 June 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05124132.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing