NCT05123716 (DEI) is a EARLY_PHASE1 clinical trial of MDMA in Interaction, Social, sponsored by University of Chicago.

Who is sponsoring NCT05123716?

NCT05123716 is sponsored by University of Chicago.

What drugs are being tested in NCT05123716?

Interventions in NCT05123716: MDMA, placebo oral tablet.

What condition does NCT05123716 study?

NCT05123716 studies Interaction, Social.

Is NCT05123716 still recruiting?

NCT05123716 is currently completed. Last updated 15 June 2022.

Last reviewed 2022-06-15 · How we verify

NCT05123716: DEI

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Drug Effects on Interpersonal Interaction

Completed EARLY_PHASE1 Last updated 15 June 2022

What this trial tests

EARLY_PHASE1 trial testing MDMA in Interaction, Social in 30 participants. Completed in 1 May 2022.

Timeline

1 August 2021

Primary endpoint
1 May 2022

1 May 2022

Quick facts

Lead sponsor	University of Chicago
Phase	EARLY_PHASE1
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	crossover
Masking	quadruple
Primary purpose	basic science
Enrollment	30
Start date	1 August 2021
Primary completion	1 May 2022
Estimated completion	1 May 2022
Sites	1 location across United States

Drugs / interventions tested

MDMA — full drug profile →
placebo oral tablet — full drug profile →

Conditions studied

Interaction, Social — all drugs for Interaction, Social →

Sponsor

University of Chicago

Who can join

Adults 18 to 35, any sex, with Interaction, Social. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

The investigators propose to use a Paired Partner design, in which subjects engage in a 45-min semi-structured conversation with one (novel) partner under the influence of MDMA and with another partner under the influence of placebo. At the end of each session, they will rate their feelings about the partner, and on the test day, subjects will be asked which partner they preferred and felt closer to.

Publications & conference data

2 peer-reviewed publications reference this trial (live from Europe PMC):

Drug-induced social connection: both MDMA and methamphetamine increase feelings of connectedness during controlled dyadic conversations.
Molla H, Lee R, Lyubomirsky S, de Wit H. · · 2023 · cited 20× · PMID 37740024 · DOI 10.1038/s41598-023-43156-0
Can research on entactogens contribute to a deeper understanding of human sexuality?
Holka-Pokorska J. · · 2023 · cited 4× · PMID 37935915 · DOI 10.1007/s43440-023-00552-7

Verify or expand the search:

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Other University of Chicago trials

Trials by the same sponsor.

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NCT07179315 — A Study Comparing Two Immunotherapy Options for Human Papillomavirus Positive HPV-Positive Head and Neck Cancer After Tr · Phase 2 · not yet recruiting
NCT07126561 — Trastuzumab Deruxtecan to Treat HER2 + Newly Diagnosed Metastatic GI Cancers · Phase 2 · not yet recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT05123716 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by University of Chicago
Last refreshed: 15 June 2022

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05123716.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing