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NCT05122728
Post-Concussion Musculoskeletal Injury Risks
trial testing Post-Concussion Neuromuscular Function and Musculoskeletal Injury Risk Assessment in Musculoskeletal Injury in 148 participants. Currently enrolling.
30 September 2026
Quick facts
| Lead sponsor | Walter Reed National Military Medical Center |
|---|---|
| Status | Recruiting now |
| Study type | OBSERVATIONAL |
| Enrollment | 148 |
| Start date | 20 October 2022 |
| Primary completion | 30 September 2026 |
| Estimated completion | 30 September 2027 |
| Sites | 3 locations across United States |
Drugs / interventions tested
- Post-Concussion Neuromuscular Function and Musculoskeletal Injury Risk Assessment
Conditions studied
- Musculoskeletal Injury — all drugs for Musculoskeletal Injury →
Sponsor
Walter Reed National Military Medical Center
Who can join
Adults 18 to 40, any sex, with Musculoskeletal Injury. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Musculoskeletal injuries (MSKI) and traumatic brain injury (TBI) are the signature injuries of the ongoing military conflicts. MSKI affect 800,000 Service Members annually and TBI have impacted more than 350,000 in the past 19 years and account for 22% of all combat casualties. Concussion, a mild form of TBI, increases MSKI risk in physically active individuals, including Service Members. The overall goal of the study is to identify the neuromuscular control mechanisms that increase MSKI risk following concussion. It is hypothesized that concussed individuals will display abnormal neuromuscular function that increases MSKI risk, as compared to non-concussed controls. The study will employ a multi-center, prospective, case-matched control observational study to identify the differences in neuromuscular function following concussion that may contribute to increased MSKI risk. Once the neuromuscular control mechanisms that increase MSKI risk following concussion are identified, targeted risk mitigation strategies can be developed to reduce MSKI risk.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Investigating post-mild traumatic brain injury neuromuscular function and musculoskeletal injury risk: A protocol for a prospective, observational, case-controlled study in service members and active individuals.
Lynall RC, Wasser JG, Brooks DI, Call JA, et al · · 2023 · cited 1× · PMID 36948547 · DOI 10.1136/bmjopen-2022-069404
Verify or expand the search:
- PubMed search for NCT05122728
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Other Walter Reed National Military Medical Center trials
Trials by the same sponsor.
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT05122728 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Walter Reed National Military Medical Center
- Last refreshed: 27 January 2026
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05122728.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing