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NCT05122676: MI-CARE
More Individualized Care: Assessment and Recovery Through Engagement
NA trial testing More Individualized Care: Assessment and Recovery through Engagement (MI-CARE) in Depression in 805 participants. Completed in 28 February 2026.
28 February 2026
Quick facts
| Lead sponsor | Kaiser Permanente |
|---|---|
| Phase | NA |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | double |
| Primary purpose | treatment |
| Enrollment | 805 |
| Start date | 10 November 2021 |
| Primary completion | 28 February 2026 |
| Estimated completion | 28 February 2026 |
| Sites | 2 locations across United States |
Drugs / interventions tested
- More Individualized Care: Assessment and Recovery through Engagement (MI-CARE)
Conditions studied
- Depression — all drugs for Depression →
- Anxiety — all drugs for Anxiety →
- Opioid-Related Disorders — all drugs for Opioid-Related Disorders →
- Pain, Chronic — all drugs for Pain, Chronic →
Sponsor
Kaiser Permanente — full company profile →
Who can join
18 and older, any sex, with Depression or Anxiety. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
The MI-CARE trial tests 12 months of telephone-based nurse care management for patients with depressive symptoms who take or have taken opioids at some time. The study tests whether offering nurse support to the patient and their primary care team that addresses these things and related issues can improve patients' health and well-being. Eligible subjects are identified automatically using health system data and randomly assigned 50:50 to either a no-contact usual care arm or to the arm offered the MI-CARE program.
Publications & conference data
2 peer-reviewed publications reference this trial (live from Europe PMC):
-
A patient-centered nurse-supported primary care-based collaborative care program to treat opioid use disorder and depression: Design and protocol for the MI-CARE randomized controlled trial.
DeBar LL, Bushey MA, Kroenke K, Bobb JF, et al · · 2023 · cited 5× · PMID 36804450 · DOI 10.1016/j.cct.2023.107124 -
A Patient-Centered Nurse-Supported Primary Care-Based Collaborative Care Program to Treat Opioid Use Disorder and Depression; Design and Protocol for the MI-CARE Randomized Controlled Trial
DeBar LL, Bushey MA, Kroenke K, Bobb JF, et al · · 2023 · DOI 10.2139/ssrn.4317717
Verify or expand the search:
- PubMed search for NCT05122676
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
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Other Kaiser Permanente trials
Trials by the same sponsor.
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- NCT07264062 — MetSense Pilot and Feasibility · NA · enrolling by invitation
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT05122676 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Kaiser Permanente
- Last refreshed: 30 March 2026
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05122676.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing