Last reviewed · How we verify

NCT05120908

Discrimination and the Brain-Gut-Microbiome (BGM) Axis

Completed Last updated 10 January 2025
What this trial tests

trial in Discrimination, Racial in 266 participants. Completed in 31 December 2024.

Timeline
24 August 2021
Primary endpoint
31 December 2024
31 December 2024

Quick facts

Lead sponsorUniversity of California, Los Angeles
StatusCompleted
Study typeOBSERVATIONAL
Enrollment266
Start date24 August 2021
Primary completion31 December 2024
Estimated completion31 December 2024
Sites1 location across United States

Conditions studied

Sponsor

University of California, Los Angeles

Who can join

Adults 18 to 50, female only, with Discrimination, Racial or Social Isolation. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Obesity is a major public health problem related to a variety of illnesses such as heart disease and diabetes. Prior research indicates that social stressors contribute to risk for obesity, possibly through alterations in diet and physical activity. However, it is not fully clear how these alterations contribute to obesity. The purpose of this study is to examine how the stressors of social isolation and discrimination relate to eating behaviors and dietary patterns, and further, how these behaviors affect the brain-gut-microbiome (BGM) connections. This study will focus on Mexican and Filipina women because research shows that they encounter a high burden of obesity and exposure to social stressors. Approximately 300 Mexican and Filipina women will be screened and enrolled. They will then provide information about social stressors via food diaries, physical body measures (e.g. waist circumference), questionnaire data regarding diet and eating behaviors, and measures of physical activity. Stool and serum will be collected to analyze microbes and metabolomics, and MRI to assess brain changes in the reward network. Analytic techniques will be used to integrate data from these multiple data sources. This analysis will determine the unique differences associated with ethnicity and social stressors in moderating eating behaviors and dietary patterns. The results of this study will provide new information about a possible pathway whereby social stressors affect behavioral, neurological and microbiome mechanisms related to obesity risk and provide new information in BGM patterns in two understudied ethnic groups. In the long term, this research may suggest possible approaches for intervention that may help reduce inequalities in obesity and related health problems.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

  1. Mediation of the association between disadvantaged neighborhoods and cortical microstructure by body mass index.
    Kilpatrick LA, Zhang K, Dong TS, Gee GC, et al · · 2023 · cited 2× · PMID 37714947 · DOI 10.1038/s43856-023-00350-5

Verify or expand the search:

Other recruiting trials for Discrimination, Racial

Currently open trials in the same condition.

Other University of California, Los Angeles trials

Trials by the same sponsor.

Verify against primary sources

Data sources for this page

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05120908.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing