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NCT05116930
Neostigmine and Glycopyrrolate for the Treatment of Post Dural Puncture Headache After Known Dural Puncture With a Tuohy Needle: A Pilot Study
Phase 2 trial testing Neostigmine in Post-Dural Puncture Headache in 18 participants. Currently enrolling.
1 December 2027
Quick facts
| Lead sponsor | Mayo Clinic |
|---|---|
| Phase | Phase 2 |
| Status | Recruiting now |
| Study type | INTERVENTIONAL |
| Allocation | na |
| Design | single group |
| Masking | none |
| Primary purpose | treatment |
| Enrollment | 18 |
| Start date | 19 November 2021 |
| Primary completion | 1 December 2027 |
| Estimated completion | 1 December 2027 |
| Sites | 1 location across United States |
Drugs / interventions tested
- Neostigmine (NEOSTIGMINE) — full drug profile →
- Glycopyrrolate — full drug profile →
Conditions studied
- Post-Dural Puncture Headache — all drugs for Post-Dural Puncture Headache →
Sponsor
Mayo Clinic
Who can join
Adults 18 to 54, female only, with Post-Dural Puncture Headache. Patients with the condition only — healthy volunteers not accepted.
What's being measured
Primary outcomes are the specific endpoints the trial is designed to prove or disprove.
-
Number of postpartum women requiring epidural blood patch
Time frame: 2 weeks
Total number of postpartum women with a post dural puncture headache (PDPH) requiring epidural blood patch (EBP)
Sponsor's own description
The purpose of this study is to evaluate Neostigmine and Glycopyrrolate to treat post-dural puncture headache (PDPH) to reduce the proportion of postpartum women with a PDPH requiring epidural blood patch (EBP) who developed a PDPH after accidental dural puncture.
Publications & conference data
No peer-reviewed publications indexed yet for this trial.
Verify or expand the search:
- PubMed search for NCT05116930
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other trials of Neostigmine
Trials testing the same drug.
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- NCT07203287 — Risk of Acute Complications With Rocuronium vs Cisatracurium in Patients With Chronic Kidney Disease · Phase 4 · recruiting
- NCT06729047 — Prophylactic Intravenous Injection of Neostigmine Plus Atropine Versus Ketorolac on Post-dural Puncture Headache in Pati · Phase 1, PHASE2 · not yet recruiting
- NCT06982092 — Using Diaphragm Ultrasonography, Sugammadex Recovers Diaphragmatic Function More Effectively Than Neostigmine. · Phase 1 · completed
Other recruiting trials for Post-Dural Puncture Headache
Currently open trials in the same condition.
- NCT06824025 — Comparison of Nebulized Neostigmine/Atropine Versus Lignocaine in Treating Acute Post-dural Puncture Headache Following · EARLY_PHASE1 · recruiting
- NCT07515456 — Theophylline, Versus Sumatriptan and Gabapentin in The Treatment of Post-Dural Puncture Headache · NA · recruiting
- NCT06253754 — Pathophysiological Mechanisms and Implication of Treatment in Postural Puncture Headache · recruiting
- NCT06444737 — Contribution of Ondansetron to Preventing Post-Dural Puncture Headaches Following Spinal Anesthesia · NA · recruiting
- NCT05804448 — Effect of Altitude on Postdural Puncture Headache After Caesarean Delivery · recruiting
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Trials by the same sponsor.
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT05116930 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Mayo Clinic
- Last refreshed: 18 March 2026
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05116930.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing