Who is sponsoring RASP?

RASP is sponsored by Bloodworks.

What condition does RASP study?

RASP studies Reversal of Platelet Aggregation Inhibitors.

What drugs are being tested in RASP?

Interventions: Autologous Room Temperature stored Platelet transfusion, Autologous Cold Stored Platelet transfusion.

Last reviewed 2021-10-27 · How we verify

Reversal of Aspirin Antiplatelet Therapy With Cold Stored Platelets (RASP)

NCT05111028 Phase 1/Phase 2 UNKNOWN

Purpose of this study is to compare the reversal responses of 4°C cold stored platelets (CSP) versus 7 day, 22°C room temperature stored platelets (RTP) when given to healthy adult subjects who have received a loading dose of aspirin antiplatelet therapy.

Details

Lead sponsor	Bloodworks
Phase	Phase 1/Phase 2
Status	UNKNOWN
Enrolment	10
Start date	2020-11-20
Completion	2021-11

Conditions

Reversal of Platelet Aggregation Inhibitors

Interventions

Autologous Room Temperature stored Platelet transfusion
Autologous Cold Stored Platelet transfusion

Primary outcomes

Glycoprotein IIb/IIIa activation at 1hr post transfusion — 1 hour after autologous transfusion
The primary endpoint is αIIbβ3 (GPIIb-IIIa) integrin activation determined by ARU (Verify Now Aspirin \[ARUTest\]) at 1h post autologous transfusion

Countries

United States