NCT05110274 (METFLEX II) is a NA clinical trial of Overnight Metabolic Flexibility in Metabolism, sponsored by Pennington Biomedical Research Center.

Who is sponsoring NCT05110274?

NCT05110274 is sponsored by Pennington Biomedical Research Center.

What drugs are being tested in NCT05110274?

Interventions in NCT05110274: Overnight Metabolic Flexibility, Clamp Metabolic Flexibility.

What condition does NCT05110274 study?

NCT05110274 studies Metabolism.

Is NCT05110274 still recruiting?

NCT05110274 is currently completed. Last updated 9 March 2023.

Last reviewed 2023-03-09 · How we verify

NCT05110274: METFLEX II

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Validating a Novel Approach to Assess Metabolic Flexibility in a Respiratory Chamber

Completed NA Last updated 9 March 2023

What this trial tests

NA trial testing Overnight Metabolic Flexibility in Metabolism in 10 participants. Completed in 8 July 2022.

Timeline

26 August 2021

Primary endpoint
8 July 2022

8 July 2022

Quick facts

Lead sponsor	Pennington Biomedical Research Center
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	na
Design	single group
Masking	none
Primary purpose	basic science
Enrollment	10
Start date	26 August 2021
Primary completion	8 July 2022
Estimated completion	8 July 2022
Sites	1 location across United States

Drugs / interventions tested

Overnight Metabolic Flexibility
Clamp Metabolic Flexibility

Conditions studied

Metabolism — all drugs for Metabolism →

Sponsor

Pennington Biomedical Research Center — full company profile →

Who can join

Adults 18 to 40, any sex, with Metabolism. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

This study is designed to test the reliability of a novel procedure for measuring metabolic flexibility, i.e., the ability to quickly adapt macronutrient oxidation to macronutrient availability, in a respiratory chamber. The investigators will compare paired measurements of metabolic flexibility determined 5-7 days apart in a metabolic chamber to assess reliability. The investigators will also compare their novel method of measuring metabolic flexibility in a respiratory chamber with a more convention method, metabolic flexibility during a hyperinsulinemic clamp.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

Validation of a novel approach to assess metabolic flexibility to a high-fat meal in a whole-body room calorimeter.
McDougal DH, Sanchez-Delgado G, Flanagan EW, Marlatt KL, et al · · 2025 · cited 1× · PMID 40051190 · DOI 10.1002/oby.24245

Verify or expand the search:

Other recruiting trials for Metabolism

Currently open trials in the same condition.

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Other Pennington Biomedical Research Center trials

Trials by the same sponsor.

NCT07530718 — Body Composition Outcomes in MS Patients · not yet recruiting
NCT07095972 — Continuous Glucose Monitoring in Metabolic Surgery · NA · not yet recruiting
NCT07139821 — Dietary Iron Requirements · recruiting
NCT07318064 — Ultra-processed Food Consumption and Health Pilot Study · NA · not yet recruiting
NCT07305753 — CanCan Body Composition Study · recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT05110274 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Pennington Biomedical Research Center
Last refreshed: 9 March 2023

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05110274.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing