Last reviewed · How we verify
NCT05107583
Effects of Pre-exercise Carbohydrate Restriction Relative to Fasting on Metabolism, Appetite, and Energy Intake in Healthy Males.
NA trial testing Low-Carbohydrate Pre-Exercise Meal in Obesity in 12 participants. Completed in 30 June 2022.
30 June 2022
Quick facts
| Lead sponsor | Nottingham Trent University |
|---|---|
| Phase | NA |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | crossover |
| Masking | single |
| Primary purpose | basic science |
| Enrollment | 12 |
| Start date | 1 September 2021 |
| Primary completion | 30 June 2022 |
| Estimated completion | 30 June 2022 |
| Sites | 2 locations across United Kingdom |
Drugs / interventions tested
- Low-Carbohydrate Pre-Exercise Meal
- High-Carbohydrate Pre-Exercise Meal
- Fasted Exercise
Conditions studied
- Obesity — all drugs for Obesity →
- Metabolic Syndrome — all drugs for Metabolic Syndrome →
Sponsor
Nottingham Trent University
Who can join
Adults 18 to 40, male only, with Obesity or Metabolic Syndrome. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
This study will compare the metabolic, appetite, energy intake, and perceptual responses to a bout of exercise completed in the evening after after a low-carbohydrate lunch meal (\<10% carbohydrate content / 0.2 g/kg carbohydrate; LO-CHO), with the responses to exercise performed after a lunch meal containing a high carbohydrate content (\~60% carbohydrate content / 2.2 g/kg carbohydrate; HI-CHO), and after skipping lunch and fasting for 8 hours since breakfast (FAST).
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Substituting Carbohydrate at Lunch for Added Protein Increases Fat Oxidation During Subsequent Exercise in Healthy Males.
Slater T, Mode WJA, Bonnard LC, Sweeney C, et al · · 2025 · cited 2× · PMID 38609167 · DOI 10.1210/clinem/dgae237
Verify or expand the search:
- PubMed search for NCT05107583
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other recruiting trials for Obesity
Currently open trials in the same condition.
- NCT07403604 — Effect of Insulin Lowering on Lipogenesis · Phase 1 · recruiting
- NCT07509307 — AMAZE 6: A Research Study Investigating How Well the Medicine NNC0487-0111 Helps People With Excess Body Weight and Knee · Phase 3 · recruiting
- NCT07272837 — Impact of Semaglutide (Ozempic/Wegovy®) on Heart and Muscle Mass · recruiting
- NCT07481630 — A Research Study Investigating How Well the Medicine NNC0487-0111 Helps People With Excess Body Weight and Knee Osteoart · Phase 3 · recruiting
- NCT07527195 — Understanding the Effect of CagriSema, Cagrilintide, and Semaglutide on Muscle Health (Role of Amylin Signature in Muscl · Phase 1 · recruiting
Other Nottingham Trent University trials
Trials by the same sponsor.
- NCT07468539 — Post-exercise Rehydration: A Randomised Cross-over Trial Comparing a 100% Fruit Beverage, a Glucose-based Sports Drink, · NA · completed
- NCT06440031 — CaMaPi for Adolescents/Young People With a History of Self-harm and Suicidal Ideation in Jos, Nigeria · NA · not yet recruiting
- NCT05148260 — Tackling Postnatal Depression: Culturally Adapted Learning Through Play Plus (LTP+) Intervention for British Mothers of · NA · not yet recruiting
- NCT05721196 — Culturally Adapted Psychoeducation (CaPE) for Bipolar Disorders in Nigeria · NA · unknown
- NCT05750277 — The Feasibility of Early Time-Restricted Eating in a Student Population · NA · unknown
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT05107583 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Nottingham Trent University
- Last refreshed: 14 September 2022
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05107583.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing