NCT05102383

Evaluation of Wear Experience With a Water Surface Daily Disposable Contact Lens

Completed NA Results posted Last updated 25 November 2025

What this trial tests

NA trial testing Comfilcon A Toric contact lenses in Contact Lens in 34 participants. Completed in 19 April 2022.

Timeline

15 November 2021

Primary endpoint
19 April 2022

19 April 2022

Quick facts

Lead sponsor	Ohio State University
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	na
Design	single group
Masking	none
Primary purpose	other
Enrollment	34
Start date	15 November 2021
Primary completion	19 April 2022
Estimated completion	19 April 2022
Sites	1 location across United States

Drugs / interventions tested

• Comfilcon A Toric contact lenses
• Verofilcon A for Astigmatism Daily Disposable contact lenses

Conditions studied

• Contact Lens — all drugs for Contact Lens →

Sponsor

Ohio State University

Who can join

Adults 18 to 40, any sex, with Contact Lens. Patients with the condition only — healthy volunteers not accepted.

Results — posted to ClinicalTrials.gov

Per-arm endpoint measurements with 95% confidence intervals where reported. Source: trial results section.

Subjective Assessment of Overall Comfort With Verofilcon A Daily Disposable Lenses for Astigmatism Primary · 3 weeks

Participants will complete a Visual Analog Scale survey of overall comfort (0-100 Scale with 0 anchored with "Poor Comfort" and 100 anchored as "Excellent Comfort")

Group	Value	95% CI
Habitual Lens Optimization Followed by Refitting With Study Lenses	91	80 – 100

Adverse events — posted to ClinicalTrials.gov

Time frame: 1 month. Reporting threshold: 0%. Adverse-event reports describe events observed during the trial — not all are caused by the drug.

All Participants

Serious: 0/30 (0%)

Deaths: 0/30

Other adverse events (1 terms — click to expand)

Reaction	System	All Participants
Hordeolum/Stye	Eye disorders	—

Data from ClinicalTrials.gov NCT05102383 adverse events section.

Sponsor's own description

The purpose of this study is to assess the wear experience of existing wearers of a monthly replacement contact lens after they have been fit with a daily disposable contact lens that has water surface treatment.

Publications & conference data

2 peer-reviewed publications reference this trial (live from Europe PMC):

1. Wear Experiences with Two Soft Contact Lenses for Astigmatism of Different Modalities.
   Fogt JS, Satiani N, Bickle KM, Wesley G, et al · · 2024 · cited 1× · PMID 38559802 · DOI 10.2147/opto.s452132
2. Wear Experience with a daily disposable soft contact lens for astigmatism in current wearers of a reusable soft toric contact lens.
   Fogt JS, Satiani N, Patton K. · · 2023 · cited 1× · PMID 38288090 · DOI 10.22374/jclrs.v7i1.54