Last reviewed · How we verify
NCT05101850
Metabolic Cost of IMT
trial in Mechanical Ventilation Complication in 40 participants. Completed in 16 May 2022.
16 May 2022
Quick facts
| Lead sponsor | Royal Brompton & Harefield NHS Foundation Trust |
|---|---|
| Status | Completed |
| Study type | OBSERVATIONAL |
| Enrollment | 40 |
| Start date | 18 October 2021 |
| Primary completion | 16 May 2022 |
| Estimated completion | 16 May 2022 |
| Sites | 1 location across United Kingdom |
Conditions studied
- Mechanical Ventilation Complication — all drugs for Mechanical Ventilation Complication →
Sponsor
Royal Brompton & Harefield NHS Foundation Trust
Who can join
18 and older, any sex, with Mechanical Ventilation Complication. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Mechanical ventilation is a life-saving intervention used worldwide. Despite this, critically ill patients who undergo mechanical ventilation commonly develop muscle weakness; this includes limb muscle weakness and diaphragmatic weakness. Physiotherapy interventions on critically ill patients include; mobilisation to improve limb muscle strength and function, and inspiratory muscle training which aims to target the diaphragm and accessory inspiratory muscles with the goal of improving endurance and strength. Whilst these interventions are standard practice in intensive care, little is known about the physiological load imposed on patients. The purpose of this study is to assess the feasibility of using indirect calorimetry (measured using the Beacon Caresystem) to measure the metabolic cost (oxygen consumption \[VO2\] and carbon dioxide production \[VCO2\]) of inspiratory muscle training and physical rehabilitation in mechanically ventilated intensive care patients.
Publications & conference data
2 peer-reviewed publications reference this trial (live from Europe PMC):
-
The metabolic cost of inspiratory muscle training in mechanically ventilated patients in critical care.
Jenkins TO, MacBean V, Poulsen MK, Karbing DS, et al · · 2023 · cited 5× · PMID 37415048 · DOI 10.1186/s40635-023-00522-6 -
Metabolic cost of physical rehabilitation in mechanically ventilated patients in critical care: an observational study.
Jenkins TO, Karbing DS, Rees SE, Poulsen MK, et al · · 2025 · PMID 40187744 · DOI 10.1136/bmjresp-2024-002878
Verify or expand the search:
- PubMed search for NCT05101850
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other recruiting trials for Mechanical Ventilation Complication
Currently open trials in the same condition.
- NCT06921655 — Targeting prEssure-Muscle-index to Avoid Ventilatory Over-Assistance During Pressure Support Ventilation · NA · recruiting
- NCT07207772 — EIT-guided PEEP Titration Versus Standard Ventilation in Bariatric Surgery · NA · recruiting
- NCT07182851 — Prevalence of Pain in Mechanically Ventilated Patients in Intensive Care Units · recruiting
- NCT06575530 — Sedation Efficacy and Safety of Remazolam Besylate in Ventilated Surgical Critically Ill Patients · Phase 4 · recruiting
- NCT06592144 — TESTO-TRIAL: Use of Testosterone in Critically Ill Patients · Phase 4 · active not recruiting
Other Royal Brompton & Harefield NHS Foundation Trust trials
Trials by the same sponsor.
- NCT07502677 — Diagnostic Accuracy of SleepImage Technology for Detecting Respiratory Failure in Patients With Amyotrophic Lateral Scle · recruiting
- NCT07498842 — Corticosteroid Tapering in Sarcoidosis · NA · recruiting
- NCT07402434 — A Prospective Study of Advanced Diagnostics in People With an Unclear Diagnosis of Cystic Fibrosis · not yet recruiting
- NCT06661278 — Evaluation of Exercise Testing and Physical Activity in Children and Adolescents Living With Inherited Arrhythmias · recruiting
- NCT06519240 — A Pilot Study Evaluating the Potential of 18F Fluorodeoxyglucose PET-CT Imaging in Diagnosing Cardiac Rejection. · NA · not yet recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT05101850 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Royal Brompton & Harefield NHS Foundation Trust
- Last refreshed: 26 May 2022
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05101850.
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