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Topical Silymarin Versus Combined Topical Silymarin and Microneedling in Treatment of Melasma: Split Face Study
Melasma is an acquired pigmentary disorder, occurring most commonly on the face. It is more prevalent in females and darker skin types. Melasma is mainly a clinical diagnosis consisting of symmetric reticulated hypermelanosis in three predominant facial patterns: centrofacial, malar, and mandibular. Melasma, though benign, can be extremely psychologically distressing and has been shown to have a significant impact on quality of life, social and emotional wellbeing. Multiple factors are implicated in the pathogenesis of melasma; however, the definite underlying mechanisms are not yet completely established. Ultraviolet exposure is one of the leading etiological factors, besides genetic and hormonal factors.
Details
| Lead sponsor | Assiut University |
|---|---|
| Phase | Phase 4 |
| Status | UNKNOWN |
| Enrolment | 30 |
| Start date | 2022-05 |
| Completion | 2022-12 |
Conditions
- Melasma
Interventions
- Silymarin
- Microneedling
Primary outcomes
- compare between the efficacy of topical silymarin alone and its combination with microneedling in treatment of melasma. — 3 months
Scoring of the patients according to modified Melasma Area and Severity Index (mMASI) score before and after treatment.