NCT05099276 is a Phase 4 clinical trial of Tranexamic Acid Pill in Knee Osteoarthritis, sponsored by Campbell Clinic.

Who is sponsoring NCT05099276?

NCT05099276 is sponsored by Campbell Clinic.

What drugs are being tested in NCT05099276?

Interventions in NCT05099276: Tranexamic Acid Pill, Placebo.

What condition does NCT05099276 study?

NCT05099276 studies Knee Osteoarthritis, Blood Loss, Pain, Postoperative.

Is NCT05099276 still recruiting?

NCT05099276 is currently status unknown. Last updated 6 March 2024.

Last reviewed 2024-03-06 · How we verify

NCT05099276

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Extended Postoperative Oral Tranexamic Acid in Knee Replacement

Status unknown Phase 4 Last updated 6 March 2024

What this trial tests

Phase 4 trial testing Tranexamic Acid Pill in Knee Osteoarthritis in 46 participants. Status unknown.

Timeline

7 December 2021

Primary endpoint
31 December 2023

1 June 2024

Quick facts

Lead sponsor	Campbell Clinic
Phase	Phase 4
Status	Status unknown
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	single
Primary purpose	other
Enrollment	46
Start date	7 December 2021
Primary completion	31 December 2023
Estimated completion	1 June 2024
Sites	1 location across United States

Drugs / interventions tested

Tranexamic Acid Pill — full drug profile →
Placebo

Conditions studied

Knee Osteoarthritis — all drugs for Knee Osteoarthritis →
Blood Loss — all drugs for Blood Loss →
Pain, Postoperative — all drugs for Pain, Postoperative →

Sponsor

Campbell Clinic

Who can join

Adults 18 to 80, any sex, with Knee Osteoarthritis or Blood Loss. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

A comparison of outcomes between use of oral tranexamic acid as compared to oral placebo in the first days after total knee replacement will be made to determine impact on clinical indications and patient reported outcomes.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

Pharmacological interventions for the prevention of bleeding in people undergoing elective hip or knee surgery: a systematic review and network meta-analysis.
Gibbs VN, Champaneria R, Sandercock J, Welton NJ, et al · · 2024 · cited 19× · PMID 38226724 · DOI 10.1002/14651858.cd013295.pub2

Verify or expand the search:

Other recruiting trials for Knee Osteoarthritis

Currently open trials in the same condition.

NCT06906939 — A Randomized Pilot rTMS Trial for Knee Arthritis Pain and Depression · EARLY_PHASE1 · recruiting
NCT05823727 — Effects of Collagen Peptide Supplementation on Connective Tissue Remodeling, Functional Outcomes, and Wound Healing Afte · NA · recruiting
NCT07370480 — Knee Osteoarthritis and Thermal Spa Treatment · NA · recruiting
NCT07507175 — Gastrocnemius Myofascial Release in Females With Knee Osteoarthritis · NA · recruiting
NCT07386600 — Dexamethasone vs Dexmedetomidine for iPACK + ACB in TKA · NA · recruiting

Other Campbell Clinic trials

Trials by the same sponsor.

NCT07115056 — Extended Oral Tranexamic Acid After Anterior Cruciate Ligament Reconstruction · Phase 4 · withdrawn
NCT06619340 — EXPAREL IPSA Block in Knee Arthroplasty · Phase 4 · enrolling by invitation
NCT05789784 — Study of Zimmer Biomet Mymobility Application on Reverse Total Shoulder Arthroplasty (RTSA) Outcomes · NA · enrolling by invitation
NCT05215236 — Opiate Sparing Protocol Randomized Controlled Trial in Open Distal Radius Fracture Repair · NA · completed
NCT04575688 — Periarticular Injection Versus Popliteal Block · Phase 4 · enrolling by invitation

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT05099276 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Campbell Clinic
Last refreshed: 6 March 2024

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05099276.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing