Helmet Noninvasive Ventilation vs. Continuous Positive Airway Pressure vs. High-flow Nasal Oxygen as First-line Treatment of Acute Hypoxemic Respiratory Failure (HENIVOT2). An Open-label, Multicentre Randomized Trial

NCT05089695 NA RECRUITING

Multicenter, open label, three-arm randomized trial to assess the effect of helmet noninvasive ventilation vs. helmet continuous positive airway pressure vs. high-flow nasal oxygen on the rate of endotracheal intubation of patients with acute moderate-to-severe hypoxemic respiratory failure

Details

Lead sponsor	Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Phase	NA
Status	RECRUITING
Enrolment	1200
Start date	2022-03-01
Completion	2026-06

Conditions

• Respiratory Failure
• Hypoxemic Respiratory Failure

Interventions

• Noninvasive respiratory support

Primary outcomes

• Rate of Endotracheal intubation — 28 days
  The proportion of patients requiring endotracheal intubation according to predefined criteria

Countries

Italy