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NCT05087758
Matrion™ Decellularized Placental Membrane in Subjects With Diabetic Foot Ulcers
NA trial testing Matrion in Diabetic Foot in 108 participants. Completed in 28 February 2025.
31 December 2024
Quick facts
| Lead sponsor | LifeNet Health |
|---|---|
| Phase | NA |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | none |
| Primary purpose | treatment |
| Enrollment | 108 |
| Start date | 1 March 2022 |
| Primary completion | 31 December 2024 |
| Estimated completion | 28 February 2025 |
| Sites | 8 locations across United States |
Drugs / interventions tested
- Matrion
- Conventional Care Wound Management
Conditions studied
- Diabetic Foot — all drugs for Diabetic Foot →
- Lower Extremity Wound — all drugs for Lower Extremity Wound →
Sponsor
LifeNet Health
Who can join
Adults 21 to 80, any sex, with Diabetic Foot or Lower Extremity Wound. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
In this study, a novel placental membrane product Matrion™ (LifeNet Health, Inc., Virginia Beach, VA) will be used as a treatment for subjects with diabetic foot ulcers. Matrion is composed of placental membrane derived from donated human birth tissue containing both the innermost amniotic layer and the outermost chorionic layer, inclusive of the trophoblast layer. Matrion is minimally processed and disinfected using a proprietary decellularization technology and terminally sterilized that safely renders the placental membrane acellular and sterile for its intended surgical applications.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Updates on Recent Clinical Assessment of Commercial Chronic Wound Care Products.
Sharma A, Sharma D, Zhao F. · · 2023 · cited 29× · PMID 37306401 · DOI 10.1002/adhm.202300556
Verify or expand the search:
- PubMed search for NCT05087758
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other recruiting trials for Diabetic Foot
Currently open trials in the same condition.
- NCT06487780 — Evaluating a Lifestyle Intervention to Prevent Recurrence of Diabetic Foot Ulcers · NA · recruiting
- NCT06674980 — Clinical Trial Assessing Human Placental Membrane Products and Standard of Care Versus Standard of Care in Nonhealing DF · NA · recruiting
- NCT06760416 — Online Diabetic Foot Support Program- Care Kit · NA · active not recruiting
- NCT06552910 — Analyzing Anesthetic Techniques in Diabetic Foot Amputation · recruiting
- NCT06526936 — The Effect of Foot Care Training Given to Diabetic Hemodialysis Patients on Foot Care Behavior · NA · recruiting
Other LifeNet Health trials
Trials by the same sponsor.
- NCT05880537 — Decellularized Femoral Artery Allograft (Nexeon AVX) Prospective Registry · recruiting
- NCT04299022 — Safety, Efficacy, & Use of ViviGen Cellular Bone Matrix Allograft in Orthopaedic Fracture Care · recruiting
- NCT03589586 — Clinical Effectiveness of DermACELL AWM in Subjects With Chronic Venous Leg Ulcers · NA · completed
- NCT03044132 — DermACELL AWM® in Chronic Wagner Grade 3/4 Diabetic Foot Ulcers · NA · completed
- NCT00411658 — Devitalized Non-valved Pulmonary Artery Allograft Implant for the Repair of Congenital Cardiac Abnormalities · NA · withdrawn
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT05087758 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by LifeNet Health
- Last refreshed: 2 April 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05087758.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing