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NCT05087615: PONV
Effects of Ondansetron, Metoclopramide and Granisetron on Perioperative Nausea and Vomiting in Patients Undergone Bariatric Surgery
Phase 3 trial testing Metoclopramide in Bariatric Surgery Candidate in 130 participants. Completed in 6 September 2021.
21 August 2021
Quick facts
| Lead sponsor | Shahid Beheshti University of Medical Sciences |
|---|---|
| Phase | Phase 3 |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | triple |
| Primary purpose | prevention |
| Enrollment | 130 |
| Start date | 1 March 2021 |
| Primary completion | 21 August 2021 |
| Estimated completion | 6 September 2021 |
| Sites | 1 location across Iran |
Drugs / interventions tested
- Metoclopramide (METOCLOPRAMIDE) — full drug profile →
- Ondansetron (ondansetron) — full drug profile →
- Metoclopramide and Ondanteron — full drug profile →
- Granisetron — full drug profile →
Conditions studied
- Bariatric Surgery Candidate — all drugs for Bariatric Surgery Candidate →
- Perioperative Complication — all drugs for Perioperative Complication →
- Nausea — all drugs for Nausea →
- Vomiting, Postoperative — all drugs for Vomiting, Postoperative →
Sponsor
Shahid Beheshti University of Medical Sciences
Who can join
Adults 13 to 75, any sex, with Bariatric Surgery Candidate or Perioperative Complication. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Post-operative nausea and vomiting (PONV) is one of the leading causes of patient morbidity after laparoscopic bariatric surgeries. A wide variety of complications related to PONV has been described, such as prolonged length of stay (LOS) in hospital, unnecessary readmissions, delay in oral intake, and bad experience for patients. Although several antiemetic regimens have been tried so far in different studies, the incidence of PONV is not significantly lowered, and it seems that it is impossible to totally eliminate it. On the other hand, the implementation of Enhanced Recovery After Surgery (ERAS) has greatly reduced the incidence of PONV and LOS. Therefore, a combination of ERAS and multiple antiemetic regimens is currently used to reduce the incidence of PONV. Nevertheless, the optimal regimen has not been found yet, and many trials are conducting to find out the best antiemetic regimen. In this randomized clinical trial, we compare four different combined and single regimens alongside the implementation of ERAS to show which regimen is more effective.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Effects of ondansetron, metoclopramide and granisetron on perioperative nausea and vomiting in patients undergone bariatric surgery: a randomized clinical trial.
Ebrahimian M, Mirhashemi SH, Oshidari B, Zamani A, et al · · 2023 · cited 11× · PMID 36809588 · DOI 10.1007/s00464-023-09939-2
Verify or expand the search:
- PubMed search for NCT05087615
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other trials of Metoclopramide
Trials testing the same drug.
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- NCT06379217 — NEPC Study: An Exploratory Safety and Efficacy Study With PSMA, SSTR2 and GRPR Targeted Radioligand Therapy in Metastati · Phase 1 · active not recruiting
- NCT06898268 — Efficacy and Safety of Ondansetron Versus Metaclopromide Treatment in Infants With Gastro Oesophageal Reflux · NA · completed
- NCT06390787 — The Efficacy of B6 and Metoclopramide Combination in Comparison With the Other Antiemetics · Phase 2, PHASE3 · completed
Other recruiting trials for Bariatric Surgery Candidate
Currently open trials in the same condition.
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- NCT06511310 — Exercise, Brain Activity, and Weight Maintenance · NA · recruiting
- NCT05966727 — Exploratory Evaluation of the Effect of Cholestyramine on Serum Levels of POPs in Obese Female Patients · NA · recruiting
- NCT06915558 — Modulation of the Inflammatory Response in Bariatric Surgery · recruiting
- NCT06689241 — Rivaroxaban Versus Enoxaparin for Prophylaxis of Venous Thromboembolism in Bariatric Surgery · NA · recruiting
Other Shahid Beheshti University of Medical Sciences trials
Trials by the same sponsor.
- NCT07005687 — Using MSCs for Chronic Active Antibody Mediated Rejection · NA · not yet recruiting
- NCT07435558 — Homogeneous vs. Heterogeneous Learning Style Grouping in Problem-Based Learning Among Nurses · NA · not yet recruiting
- NCT07408492 — Impact of AI-Based Research Training on Nursing Students · NA · not yet recruiting
- NCT07176663 — Efficacy and Safety of Tirzepatide (Spartina) in Chronic Kidney Failure · NA · not yet recruiting
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT05087615 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Shahid Beheshti University of Medical Sciences
- Last refreshed: 29 October 2021
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05087615.
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