Who is sponsoring NCT05083455?

NCT05083455 is sponsored by Brigham and Women's Hospital.

What drugs are being tested in NCT05083455?

Interventions in NCT05083455: Rivaroxaban, Enoxaparin.

What condition does NCT05083455 study?

NCT05083455 studies Deep Vein Thrombosis, Pulmonary Embolus.

Is NCT05083455 still recruiting?

NCT05083455 is currently completed. Last updated 27 July 2023.

Last reviewed 2023-07-27 · How we verify

NCT05083455

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Replication of the RECORD1 Anticoagulant Trial in Healthcare Claims Data

Completed Last updated 27 July 2023

What this trial tests

trial testing Rivaroxaban in Deep Vein Thrombosis, Pulmonary Embolus in 89,215 participants. Completed in 22 July 2021.

Timeline

22 September 2020

Primary endpoint
21 July 2021

22 July 2021

Quick facts

Lead sponsor	Brigham and Women's Hospital
Status	Completed
Study type	OBSERVATIONAL
Enrollment	89,215
Start date	22 September 2020
Primary completion	21 July 2021
Estimated completion	22 July 2021
Sites	1 location across United States

Drugs / interventions tested

Rivaroxaban (rivaroxaban) — full drug profile →
Enoxaparin — full drug profile →

Conditions studied

Deep Vein Thrombosis, Pulmonary Embolus — all drugs for Deep Vein Thrombosis, Pulmonary Embolus →

Sponsor

Brigham and Women's Hospital

Who can join

Adults 18 to 120, any sex, with Deep Vein Thrombosis, Pulmonary Embolus. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Investigators are building an empirical evidence base for real world data through large-scale replication of randomized controlled trials. The investigators' goal is to understand for what types of clinical questions real world data analyses can be conducted with confidence and how to implement such studies.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

A Benchmark, Expand, and Calibration (BenchExCal) Trial Emulation Approach for Using Real-World Evidence to Support Indication Expansions: Design and Process for a Planned Empirical Evaluation.
Wang SV, Russo M, Glynn RJ, Bradley MC, et al · · 2025 · cited 7× · PMID 40067205 · DOI 10.1002/cpt.3621

Verify or expand the search:

Other trials of Rivaroxaban

Trials testing the same drug.

NCT06953726 — Comparing the Safety and Efficacy of Apixaban and Rivaroxaban · Phase 4 · not yet recruiting
NCT07468448 — Combination Antithrombotic Treatment for Prevention of Recurrent Ischemic Stroke in IntraCranial Atherosclerotic diseaSe · Phase 3 · not yet recruiting
NCT07318610 — Reducing Adverse Vascular Outcomes With Factor XI Inhibition in Adult Participants With Peripheral Artery Disease · Phase 3 · not yet recruiting
NCT07312851 — A Study to Investigate Andexanet Dosing and the Interaction Between Andexanet and Subsequent Enoxaparin in Healthy Parti · Phase 1 · recruiting
NCT06961630 — Post-Operative Biomarker-Guided Precision Medicine For Cardiovascular Risk Reduction · EARLY_PHASE1 · recruiting

Other Brigham and Women's Hospital trials

Trials by the same sponsor.

NCT07011758 — Dynamic Treatment Regimes for Opioid Use Disorder · Phase 2 · not yet recruiting
NCT06310018 — Augmented Ultrasound-Facilitated, Catheter-Directed Fibrinolysis for PE · suspended
NCT04519177 — Randomized Trial of a Sleep Disorders Program on Firefighter Safety and Disability ... · NA · not yet recruiting
NCT06355986 — Computerized Decision Support to Prevent Stroke in Atrial Fibrillation · NA · not yet recruiting
NCT06099275 — Evaluation of Hemodynamics in People With Untreated Preeclampsia Using Echocardiography · suspended

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT05083455 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Brigham and Women's Hospital
Last refreshed: 27 July 2023

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05083455.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing