NCT05083442 (LLLT) is a NA clinical trial of Low Level Laser Therapy in Overweight and Obesity, sponsored by Mayo Clinic.

Who is sponsoring NCT05083442?

NCT05083442 is sponsored by Mayo Clinic.

What drugs are being tested in NCT05083442?

Interventions in NCT05083442: Low Level Laser Therapy, Sham (placebo).

What condition does NCT05083442 study?

NCT05083442 studies Overweight and Obesity, Weight Loss.

Is NCT05083442 still recruiting?

NCT05083442 is currently completed. Last updated 3 April 2025.

Are results published for NCT05083442?

Yes — primary outcome results have been posted to ClinicalTrials.gov. See the outcomes section above for details.

Last reviewed 2025-04-03 · How we verify

NCT05083442: LLLT

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Low-level Laser and Lifestyle Modifications

Completed NA Results posted Last updated 3 April 2025

What this trial tests

NA trial testing Low Level Laser Therapy in Overweight and Obesity in 60 participants. Completed in 30 December 2024.

Timeline

1 June 2022

Primary endpoint
30 April 2024

30 December 2024

Quick facts

Lead sponsor	Mayo Clinic
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	single
Primary purpose	treatment
Enrollment	60
Start date	1 June 2022
Primary completion	30 April 2024
Estimated completion	30 December 2024
Sites	1 location across United States

Drugs / interventions tested

Low Level Laser Therapy — full drug profile →
Sham (placebo)

Conditions studied

Overweight and Obesity — all drugs for Overweight and Obesity →
Weight Loss — all drugs for Weight Loss →

Sponsor

Mayo Clinic

Who can join

18 and older, any sex, with Overweight and Obesity or Weight Loss. Patients with the condition only — healthy volunteers not accepted.

Results — posted to ClinicalTrials.gov

Per-arm endpoint measurements with 95% confidence intervals where reported. Source: trial results section.

Change in Fat Mass From Baseline to 6 Weeks Primary · 6 weeks

The change in fat mass from baseline to the end of treatments at 6 weeks

Group	Value	95% CI
Group 1 - LLLT	-1.3	± 1.5
Group 2 - SHAM	-2.0	± 2.4

Change in Waist Circumference From Baseline to 6 Weeks Primary · 6 weeks

The change in waist circumference from baseline to the end of treatments at 6 weeks

Group	Value	95% CI
Group 1 - LLLT	-1.8	± 3.5
Group 2 - SHAM	-1.8	± 4.0

Adverse events — posted to ClinicalTrials.gov

Time frame: AE's were collected over the 6 weeks of the LLLT intervention.. Reporting threshold: 1%. Adverse-event reports describe events observed during the trial — not all are caused by the drug.

Group 1 - LLLT

Serious: 0/30 (0%)

Deaths: 0/30

Group 2 - SHAM

Serious: 0/30 (0%)

Deaths: 0/30

Other adverse events (3 terms — click to expand)

Reaction	System	Group 1 - LLLT	Group 2 - SHAM
Loose Stool	Gastrointestinal disorders	—	—
muscle contraction/tingling	Musculoskeletal and connective tissue disorders	—	—
stomach/gas pain	Gastrointestinal disorders	—	—

Data from ClinicalTrials.gov NCT05083442 adverse events section.

Sponsor's own description

The purpose of this research study is to evaluate the effectiveness of Low Level Laser Therapy in combination with Lifestyle Modifications in helping people reduce the extra weight and size in the central body region

Publications & conference data

No peer-reviewed publications indexed yet for this trial. Completed trials usually publish results within 12-18 months.

Verify or expand the search:

Other trials of Low Level Laser Therapy

Trials testing the same drug.

NCT07531654 — Comparative Effectiveness of Standard and Modified Laser Therapy in Myofascial Pain Management. · NA · not yet recruiting
NCT07043868 — Effects and Feasibility of Photobiomodulation at 830nm Nanometers in the Treatment of Diabetic Ulcers · NA · not yet recruiting
NCT07273591 — Effects of Low-level Laser Therapy on Spasticity and Gait Parameters in Chronic Stroke Patients With Spastic Plantar Fle · NA · recruiting
NCT07128134 — Evaluation of the Effects of the Low-level Laser Therapy as an Adjunct to Nonsurgical Treatment in Patients With Periimp · NA · not yet recruiting
NCT06759454 — Comparison of LASER Therapy and Desensitizing Agents in Dentinal Hypersensitivity · NA · not yet recruiting

Other recruiting trials for Overweight and Obesity

Currently open trials in the same condition.

NCT06282952 — Health Outcomes in C-Section Infants With Fecal Microbiota Transplantation · NA · recruiting
NCT07406191 — WB-EMS Effects on Cardiometabolic Risk Factors · NA · recruiting
NCT07230496 — A Study to Investigate Safety, Tolerability and Pharmacokinetics of LAE103 or LAE103 in Combination With LAE102 in Healt · Phase 1 · recruiting
NCT07313761 — A Trial to Compare the Extent to Which Maridebart Cafraglutide (AMG 133) is Made Available in the Body When Administered · Phase 1 · active not recruiting
NCT07165431 — Effect of a Postbiotic Supplementation in Overweight and Obese Subjects: A Randomized Controlled Trial (PARABIOTICS-2). · NA · recruiting

Other Mayo Clinic trials

Trials by the same sponsor.

NCT07126548 — A Point of Prostate Cancer Diagnosis Virtual Reality Assistant Intervention in Supporting Newly Diagnosed Black Men · NA · not yet recruiting
NCT07221656 — Evaluation of Prolonged Asparaginase Activity Levels After Calaspargase Pegol Administration · not yet recruiting
NCT06891001 — The Utilization of a Shoe Insert on Individuals With Unilateral Greater Trochanteric Pain Syndrome on Single Leg Stance, · NA · not yet recruiting
NCT07169799 — Impact of Cryotherapy Spray (Tru-Freeze) for the Eradication of Gastric Antral Vascular Ectasia (ICE-GAVE) · NA · recruiting
NCT07086183 — Perioperative Risk in Patients on Chronic Aspirin Undergoing Craniotomy · not yet recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT05083442 (US National Library of Medicine, public domain)
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Mayo Clinic
Last refreshed: 3 April 2025

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05083442.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing