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NCT05082454: ASCEND
Post Market Clinical Follow-Up Study in Patients Treated With the On-X Ascending Aortic Prosthesis (AAP)
trial testing Open repair in Aortic Valve Disease in 108 participants. Participants enrolled and being followed up; not accepting new ones.
6 February 2024
Quick facts
| Lead sponsor | JOTEC GmbH |
|---|---|
| Status | Active, enrolled |
| Study type | OBSERVATIONAL |
| Enrollment | 108 |
| Start date | 20 October 2021 |
| Primary completion | 6 February 2024 |
| Estimated completion | 31 March 2029 |
| Sites | 11 locations across Italy, United Kingdom, Germany, United States, Spain |
Drugs / interventions tested
- Open repair
Conditions studied
- Aortic Valve Disease — all drugs for Aortic Valve Disease →
Sponsor
JOTEC GmbH
Who can join
18 and older, any sex, with Aortic Valve Disease. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
The ASCEND post-market clinical follow-up study is undertaken to evaluate safety and clinical performance of the On-X Ascending Aortic Prosthesis (AAP) used in surgical aortic valve replacement.
Publications & conference data
No peer-reviewed publications indexed yet for this trial.
Verify or expand the search:
- PubMed search for NCT05082454
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other trials of Open repair
Trials testing the same drug.
- NCT05145517 — A Post-Market Clinical Follow-up Study in Patients Treated With Vascular Grafts · recruiting
- NCT04986709 — PMCF Study in Patients With Acute or Chronic Aortic Dissection or Aortic Aneurysm Treated With E-vita OPEN NEO · active not recruiting
- NCT06483516 — Post-operative Quality of Life After AAA Management: EVAR Versus Open Repair · recruiting
- NCT04676672 — A PMCF Study in Patients With Acute or Chronic Aortic Dissection or Aortic Aneurysm Treated With E-vita OPEN NEO · active not recruiting
Other recruiting trials for Aortic Valve Disease
Currently open trials in the same condition.
- NCT07008911 — CardioHeartConnect: Commercially Available Fitness for Cardiac Rehabilitation · NA · recruiting
- NCT07267117 — Cohort Observing Mechanisms, Progression and Sequelae of Valvular Heart Disease · recruiting
- NCT07021612 — A Clinical and Imaging Registry of Transcatheter Aortic Valve Implantation Using JenaValve System/ J-Valve System for Pa · recruiting
- NCT06896227 — TAVR: The Impact of Prothesis Positioning on Valvular and Coronary Hemodynamics · NA · recruiting
- NCT06189976 — Rapid Atrial Pacing After TAVI to Predict Pacemaker Implantation · NA · recruiting
Other JOTEC GmbH trials
Trials by the same sponsor.
- NCT05721001 — French Registry Conducted on E-vita OPEN NEO · active not recruiting
- NCT05145517 — A Post-Market Clinical Follow-up Study in Patients Treated With Vascular Grafts · recruiting
- NCT04986709 — PMCF Study in Patients With Acute or Chronic Aortic Dissection or Aortic Aneurysm Treated With E-vita OPEN NEO · active not recruiting
- NCT04765176 — A PMCF Study in Patients With Infrarenal Aortic Aneurysm Treated With the E-tegra Stent Graft System · active not recruiting
- NCT04676672 — A PMCF Study in Patients With Acute or Chronic Aortic Dissection or Aortic Aneurysm Treated With E-vita OPEN NEO · active not recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT05082454 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by JOTEC GmbH
- Last refreshed: 5 February 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05082454.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing