Last reviewed · How we verify
NCT05081895
Ventilation and Perfusion in the Respiratory System
trial testing Electrical Impedance tomography in Respiratory Failure in 16 participants. Completed in 18 December 2023.
18 December 2023
Quick facts
| Lead sponsor | University of California, San Diego |
|---|---|
| Status | Completed |
| Study type | OBSERVATIONAL |
| Enrollment | 16 |
| Start date | 19 August 2021 |
| Primary completion | 18 December 2023 |
| Estimated completion | 18 December 2023 |
| Sites | 1 location across United States |
Drugs / interventions tested
- Electrical Impedance tomography
- Lung mechanics and gas exchange
Conditions studied
- Respiratory Failure — all drugs for Respiratory Failure →
- Respiratory Distress Syndrome, Adult — all drugs for Respiratory Distress Syndrome, Adult →
- Critical Illness — all drugs for Critical Illness →
- Pulmonary Disease — all drugs for Pulmonary Disease →
Sponsor
University of California, San Diego
Who can join
18 and older, any sex, with Respiratory Failure or Respiratory Distress Syndrome, Adult. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Respiratory failure occurs when the lung fails to perform one or both of its roles in gas exchange; oxygenation and/or ventilation. Presentations of respiratory failure can be mild requiring supplemental oxygen via nasal cannula to more severe requiring invasive mechanical ventilation as see in acute respiratory distress syndrome (ARDS).It is important to provide supportive care through noninvasive respiratory support devices but also to minimize risk associated with those supportive devices such as ventilator induced lung injury (VILI) and/or patient self-inflicted lung injury (P-SILI). Central to risk minimization is decreasing mechanical stress and strain and optimizing transpulmonary pressure or the distending pressure across the lung, minimizing overdistention and collapse. Patient positioning impacts ventilation/perfusion and transpulmonary pressure. Electrical impedance tomography (EIT) is an emerging technology that offers a noninvasive, real-time, radiation free method to assess distribution of ventilation at the bedside. The investigators plan to obtain observational data regarding distribution of ventilation during routine standard of care in the ICU, with special emphasis on postural changes and effects of neuromuscular blockade, to provide insight into ventilation/perfusion matching, lung mechanics in respiratory failure, other pulmonary pathological processes.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Impact of Supine Versus Semirecumbent Body Posture on the Distribution of Ventilation in Acute Respiratory Distress Syndrome.
Pearce AK, McGuire WC, Elliott AR, Goligher EC, et al · · 2023 · cited 3× · PMID 38053751 · DOI 10.1097/cce.0000000000001014
Verify or expand the search:
- PubMed search for NCT05081895
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other trials of Electrical Impedance tomography
Trials testing the same drug.
- NCT04603755 — Electrical Impedance Tomography: Collapse in Dependent Areas as a Predictor of Response to Prone Position Ventilation in · completed
- NCT04011852 — The Role of Chest Electrical Impedance Tomography in the Pediatric Ventilator Weaning · completed
Other recruiting trials for Respiratory Failure
Currently open trials in the same condition.
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Other University of California, San Diego trials
Trials by the same sponsor.
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- NCT07524751 — Culturally Adapted Pain Management for Indigenous Peoples · NA · not yet recruiting
- NCT07518784 — Accurate Point of Care Liver Disease Diagnostics (Phase 2) · recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT05081895 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by University of California, San Diego
- Last refreshed: 10 December 2024
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05081895.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing