NCT05059431

The Effect of Human Prostate Tissue on Platelet Activation

Completed Last updated 28 September 2021

What this trial tests

trial in Prostate Hyperplasia in 8 participants. Completed in 24 April 2017.

Timeline

4 February 2015

Primary endpoint
24 April 2017

24 April 2017

Quick facts

Lead sponsor	Tri-Service General Hospital
Status	Completed
Study type	OBSERVATIONAL
Enrollment	8
Start date	4 February 2015
Primary completion	24 April 2017
Estimated completion	24 April 2017

Conditions studied

• Prostate Hyperplasia — all drugs for Prostate Hyperplasia →
• Coagulation; Intravascular — all drugs for Coagulation; Intravascular →
• Thrombotic Disorder — all drugs for Thrombotic Disorder →

Sponsor

Tri-Service General Hospital

Who can join

Adults 40 to 80, male only, with Prostate Hyperplasia or Coagulation; Intravascular. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Transurethral resection of the prostate (TURP) is a common and standard urological surgical procedure for managing benign prostatic hyperplasia (BPH). Although surgical technology improved in recent decades, severe complications such as TURP syndrome, hematuria, and postoperative hemorrhage were still considerable. Coagulopathy is one of rare but devastating complication which may contribute to bleeding during and after TURP. Although the exact pathophysiological condition of coagulopathy is not clear, there are several possible mechanisms of TURP associated coagulopathy including: urokinase- (u-PA) and tissue-type plasminogen activator (t-PA)-related fibrinolysis; absorption of irrigating fluid associated dilutional coagulopathy; release of prostatic particles rich in tissue thromboplastins into the circulation causing secondary fibrinolysis and disseminated intravascular coagulopathy (DIC); sepsis with DIC associated with bacteria entering the circulation due to prostatic venous sinuses opening and the using of high pressure irrigation. On the other hand, platelet are essential to hemostasis and thrombosis and its activation also contributes to leukocyte recruitment and DIC. Furthermore, previous studies demonstrated that activated platelets could express TLR4, CD40L, P-selectin and induce platelet-leukocyte aggregation (PLA), which were considered important for systemic inflammatory responses and DIC development. Currently, no study investigating the association of prostate particle and platelet activation. Here, we tested the hypothesis that prostate tissue may induce inflammatory responses through platelet activation by measuring the expression of TLR4, CD40L, P-selectin and PLA on platelets.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

1. Prostate Tissue-Induced Platelet Activation and Platelet-Neutrophil Aggregation Following Transurethral Resection of the Prostate Surgery: An In Vitro Study.
   Lin PA, Huang HH, Hu MH, Huang GS, et al · · 2025 · cited 1× · PMID 40299686 · DOI 10.3390/biomedicines13041006