Last reviewed · How we verify
NCT05058924: LEAP
Low Molecular Weight hEparin vs. Aspirin Post-partum
NA trial testing Prophylactic low molecular weight heparin in Venous Thromboembolism in 30 participants. Completed in 1 March 2024.
29 February 2024
Quick facts
| Lead sponsor | Mount Sinai Hospital, Canada |
|---|---|
| Phase | NA |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | none |
| Primary purpose | prevention |
| Enrollment | 30 |
| Start date | 29 August 2021 |
| Primary completion | 29 February 2024 |
| Estimated completion | 1 March 2024 |
| Sites | 1 location across Canada |
Drugs / interventions tested
- Prophylactic low molecular weight heparin — full drug profile →
- Low molecular weight heparin and low-dose aspirin
Conditions studied
- Venous Thromboembolism — all drugs for Venous Thromboembolism →
Sponsor
Mount Sinai Hospital, Canada
Who can join
18 and older, female only, with Venous Thromboembolism. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
This is single centre pilot, randomized controlled trial assessing postpartum prophylactic anticoagulation with 3 weeks of LMWH followed by 3 weeks of Aspirin compared to standard of care of prophylactic LMWH for 6 weeks at moderate to high risk of developing VTE.
Publications & conference data
2 peer-reviewed publications reference this trial (live from Europe PMC):
-
Prevention, diagnosis, and management of PE and DVT in pregnant women.
Kevane B, Áinle FN. · · 2023 · cited 7× · PMID 38066865 · DOI 10.1182/hematology.2023000476 -
Low-molecular-weight heparin vs aspirin postpartum (LEAP): a single-center pilot randomized control trial.
Vlachodimitropoulou E, Malinowski K, Kaplovitch E, Carrier M, et al · · 2025 · PMID 41280308 · DOI 10.1016/j.bvth.2025.100106
Verify or expand the search:
- PubMed search for NCT05058924
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other recruiting trials for Venous Thromboembolism
Currently open trials in the same condition.
- NCT07399977 — Using a Blood Test and Software Tool to Guide Treatment for Venous Thromboembolism · NA · recruiting
- NCT06861088 — The Effect of Kinisoquin™ on Thromboembolic Events in Patients With Metastatic or Locally Advanced Pancreatic Cancer · Phase 3 · recruiting
- NCT07140523 — A Study to Compare the Efficacy and Safety of SRSD107 and Enoxaparin in Adult Subjects Undergoing TKA · Phase 2 · recruiting
- NCT04211181 — CHIPs-VTE Study in Hospitalized Patients to Prevent Hospital-Acquired Venous Thromboembolism · NA · recruiting
- NCT06440694 — Colchicine to Quench the Inflammatory Response After Deep Vein Thrombosis (The Conquer-DVT Pilot Trial) · Phase 3 · recruiting
Other Mount Sinai Hospital, Canada trials
Trials by the same sponsor.
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- NCT06546254 — 1% Lidocaine Paracervical Block for Endometrial Biopsy · NA · completed
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT05058924 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Mount Sinai Hospital, Canada
- Last refreshed: 3 March 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05058924.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing